Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum.

Introduction: Glial fibrillary acidic protein (GFAP) may contribute to Alzheimer's pathology at early disease stages. GFAP moderation of Alzheimer's disease (AD)-related neurodegeneration and cognition is unclear.

Methods: We examined plasma GFAP moderation of AD biomarkers (amyloid beta [Aβ]-positron emission tomography [PET][A]; plasma phosphorylated tau-181 [p-tau181][T]), neurodegeneration (plasma NfL[N]; structural magnetic resonance imaging [MRI][N]), and cognition (Cog; Cog) in two cohorts: University of California San Francisco (UCSF) (N = 212, 91.

A simplified hybrid capture approach retains high specificity and enables PCR-free workflow.

Background: Hybrid capture is a critical technology for selective enrichment of genomic regions of interest in genomic analysis. Despite its widespread adoption, the core methodology has remained largely unchanged for over 15 years, with traditional workflows involving time-consuming bead-based capture steps, multiple temperature-controlled washes, and post-hybridization PCR. These steps introduce workflow complexity, increase turnaround time, and can negatively impact library complexity and variant calling accuracy.

The Get to Know Me Board in the Neonatal Intensive Care Unit: A Mixed-Methods Study.

Background: Research on effectiveness of the Get to Know Me board, a patient- and family-centered care intervention, is limited to adult inpatients.

Objectives: This mixed-methods study examined the effect of a neonatal intensive care unit (NICU)-specific Get to Know Me board on perceptions of empathy, trust, and satisfaction among nurses and families.

Methods: Seventy families of NICU patients and 39 bedside nurses across 5 single-patient room clusters were enrolled.

Practical implementation of m-Plane GaN resonant-phonon Terahertz quantum cascade laser.

In this study, we analyze a novel m-plane GaN Terahertz Quantum Cascade Laser (THz QCL) with a resonant phonon depopulation scheme using the Non-equilibrium Green's Function (NEGF) approach. This design offers a more practical alternative to the previously proposed Two-Well (TW) GaN THz QCL, featuring significantly lower operating currents, reducing the risk of thermal damage, and greatly enhances the feasibility of experimental realization. The addition of an extra barrier also reduces leakage into the continuum and into the excited states.