Treatment practices of childhood pneumonia: the perspective of caregivers. A community-based study in West Bengal.

Pneumonia, an acute lower respiratory infection, is the single largest infectious cause of death in children worldwide. In this study, we aimed to assess the treatment practices of parents/caregivers for the management of pneumonia in children under 5 years of age in a rural community of West Bengal and to determine the associated causal factors. About 200 children were randomly selected by the multi-stage sampling method from two health and wellness centers.

Bridging the gap: Extracellular matrix-based strategies for peripheral nerve regeneration and neuropathic pain management.

Peripheral neuropathic pain, arising from peripheral nerve injuries, remains a significant clinical challenge because of complex pathophysiology and limited treatment options. Conventional treatments primarily provide symptomatic relief, failing to address underlying nerve damage. The extracellular matrix (ECM) plays a vital role in nerve regeneration by offering structural support and biochemical signals that regulate Schwann cell behaviour, axonal growth and microenvironment remodelling.

Novel 2D MXenes biocomposite for the removal of emerging organic contaminants from wastewater.

Growing ecological and public health issues brought on by the increasing presence of novel organic contaminants in wastewater need the development of innovative remediation solutions. It's usually challenging for conventional treatment methods to effectively collect these contaminants, which include pharmaceuticals, personal care products, and industrial chemicals. Scientists are, therefore, concentrating on innovative material to increase the efficiency of adsorption and removal.

Optimization and validation of the international metabolic prognostic index for CD19 CAR-T in large B-cell lymphoma.

While CD19-directed CAR T-cell therapy represents a transformative immunotherapy for relapsed/refractory large B-cell lymphoma (r/r LBCL), more than 50% of patients ultimately progress or relapse. Recently, the International Metabolic Prognostic Index (IMPI) - incorporating age, stage, and metabolic tumor volume (MTV) - was shown to improve prognostication for LBCL frontline treatment. Here, we examine its utility to predict toxicity and survival in CAR-T recipients.

Implementing TB preventive therapy: lessons from a large-scale initiative in India.

TB infection management is essential in addressing the global TB burden. TB programmes worldwide are focusing on WHO-recommended shorter duration TB preventive treatment (TPT). We document early findings of 3HP regimen (rifapentine-isoniazid weekly doses for 3 months) implementation under the Joint Effort for Elimination of Tuberculosis (JEET) project in India.