Reducing motion artifacts in craniocervical background subtraction angiography with deformable registration and unsupervised deep learning.

Background: In clinical practice, digital subtraction angiography (DSA) often suffers from misregistration artifact resulting from voluntary, respiratory, and cardiac motion during acquisition. Most prior efforts to register the background DSA mask to subsequent postcontrast images rely on key point registration using iterative optimization, which has limited real-time application.

Purpose: Leveraging state-of-the-art, unsupervised deep learning, we aim to develop a fast, deformable registration model to substantially reduce DSA misregistration in craniocervical angiography without compromising spatial resolution or introducing new artifacts.

NEK9-mediated Wnt signalling repressor TLE3 rewires Docetaxel resistance in cancer cells by inducing pyroptosis.

Background: Docetaxel is the most common chemotherapy regimen for several neoplasms, including advanced OSCC (Oral Squamous Cell Carcinoma). Unfortunately, chemoresistance leads to relapse and adverse disease outcomes.

Methods: We performed CRISPR-based kinome screening to identify potential players of Docetaxel resistance.

Evaluation of hepatotoxicity due to conditioning regimens in beta thalassemia major and aplastic anemia patients undergoing bone marrow transplantation.

IntroductionConditioning regimen-related hepatotoxicity is one of the frequent causes of morbidity and mortality in hematological disorder patients undergoing bone marrow transplantation-the current study aimed to evaluate the effects of conditioning regimens on liver enzymes.MethodsThis observational analytical study was conducted for one year and recruited patients who received conditioning regimens before undergoing Bone Marrow Transplantation for benign hematological disorder [aplastic anemia (AA) and beta-thalassemia major (BTM)]. Pre-and post-transplant assessment particularly liver function test was done.

Exploring the Feasibility of Daycase Pediatric Tonsillectomy in a Tertiary Care Hospital: A Retrospective Review.

Introduction Tonsillectomy, with or without adenoidectomy, is one of the most commonly performed procedures in pediatric otolaryngology. Over the years, there has been a shift in postoperative practice from routine admissions to daycase procedures. The study aimed to evaluate the postoperative course of pediatric tonsillectomy with or without adenoidectomy in a local tertiary care hospital, and to compare our current practices with the internationally published data on the subject.

Managing Laryngeal Carcinoma in the United Arab Emirates: An Experience From the Tertiary Care Center.

Background Laryngeal cancer is a common head and neck malignancy. The treatment modalities differ depending on the clinical staging and location of the tumor, hence affecting the survival outcomes. Objective This study aims to provide demographic information and survival outcomes in laryngeal cancer patients in the UAE, considering the clinical staging and treatment received.