Environment-dependent selection impacts heritable developmental stability and trait canalization in rice.

Canalization, or the maintenance of trait values regardless of environmental or genetic variability, is fundamentally important for maintaining developmental stability. While this concept was described decades ago, we still know relatively little about how canalization is influenced by environmental stress, how it is shaped by natural selection, and the genetic underpinnings of canalization. In this study, we examined natural selection on microenvironmental canalization in rice () in wet and dry field conditions.

"We're all in it together": uniting a diverse range of professionals and people with lived experience within the development of a complex, theory-based paediatric speech and language therapy intervention.

Background: It is increasingly commonplace to involve relevant professionals and people with lived experience within healthcare research. Although valuable case studies regarding such involvement exist, there is currently a paucity of case studies highlighting the professional and personal impacts of uniting a diverse group of professionals and people with lived experience within the development of new, theory-based interventions. The aim of this paper is to provide insight into the impacts of involving a diverse range of individuals, unified within a single steering group, within the development of a new, theory-based, paediatric speech and language therapy intervention ("Supporting Words and Sounds" - SWanS).

Co-design to consensus: Identifying the core elements of a novel intervention for pre-school children with co-occurring phonological speech sound disorder (SSD) and developmental language disorder (DLD) using a modified e-Delphi approach.

Introduction: Although frequently seen in clinical services, there are few interventions which have been developed specifically to meet the needs of pre-school children with co-occurring features of a phonological speech sound disorder (P-SSD) and developmental language disorder (DLD). This study aims to achieve consensus on the core elements of a novel intervention for pre-school children with co-occurring features of P-SSD and DLD ("SWanS"- Supporting Words and Sounds), where expressive vocabulary and speech comprehensibility are joint outcomes of interest.

Methods: Forty-seven potential core intervention elements, based on a priori findings and the wider literature, were generated by a diverse steering group of professionals and people with lived experience within a systematic co-design process.

Economic impact of the Elecsys anti-Müllerian hormone Plus immunoassay for anti-Müllerian hormone testing as part of polycystic ovary syndrome assessment in the United Kingdom.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women. Current international PCOS assessment and management guidelines recommend anti-Müllerian hormone (AMH) as an alternative to transvaginal ultrasound for assessing polycystic ovarian morphology, which is one of three criteria for diagnosing PCOS. This study assessed the economic impact of using the Elecsys® AMH Plus immunoassay (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) for AMH testing in the United Kingdom health system to assess women with signs and symptoms of PCOS.

Rapid adaptation and extinction across climates in synchronized outdoor evolution experiments of .

Climate change is threatening species with extinction, and rapid evolutionary adaptation may be their only option for population rescue over short ecological timescales. However, direct observations of rapid genetic adaptation and population dynamics across climates are rare across species. To fill this gap, we conducted a replicated, globally synchronized evolution experiment with the plant for 5 years in over 30 outdoor experimental gardens with distinct climates across Europe, the Levant, and North America.