The Development of Malignant Melanoma Concurrent to Encorafenib and Cetuximab Therapy for Gastrointestinal Cancer With Neuroendocrine Features.

BRAF inhibitors, among other targeted therapies, have transformed the treatment of many cancers in recent years. While cutaneous malignancies are a known adverse effect of BRAF inhibitors, the following case description highlights the importance of regularly monitoring patients on these therapies for new or changing skin lesions. A female in her 70s presented to the dermatology clinic with the sudden development of several new, dark nevi one month after the initiation of encorafenib with cetuximab for neuroendocrine carcinoma.

A hot-Jupiter progenitor on a super-eccentric retrograde orbit.

Giant exoplanets orbiting close to their host stars are unlikely to have formed in their present configurations. These 'hot Jupiter' planets are instead thought to have migrated inward from beyond the ice line and several viable migration channels have been proposed, including eccentricity excitation through angular-momentum exchange with a third body followed by tidally driven orbital circularization. The discovery of the extremely eccentric (e = 0.

Limitations of Computed Tomography Angiography in Preoperative Planning of Peroneus Brevis Rotational Flap.

Unlabelled: The distally based peroneus brevis (PB) rotational flap has been shown to be a reliable method of coverage of distal third tibial wounds. The flap is perfused via retrograde flow from distal PB perforators located within 8 cm of the lateral malleolus. The ability to assess patency of these vessels preoperatively facilitates surgical planning, and computed tomography angiography (CTA) has been used for perforator assessment of other lower extremity flaps.

Firearm Injuries to the Wrist and Hand in Children and Adults: An Epidemiologic Study.

Background: Gunshot wounds (GSWs) to the wrist and hand are a major health and economic burden in the United States. There are few studies examining the circumstances and epidemiological factors surrounding these injuries. This study assesses the epidemiological factors, as well as the shooting circumstances, injury details, and surgical management of wrist and hand GSWs in children and adults.