Tailored Reconstruction of Low- and High-Flow cerebrospinal fluid Leaks: A Single-Center, 1-Year Analysis Following 656 Endoscopic Endonasal Surgeries.

Background And Objectives: The endoscopic endonasal approach (EEA) has become a key surgical method for managing midline skull base lesions, offering minimally invasive access with reduced morbidity. One of the most significant complications following EEA is cerebrospinal fluid (CSF) leakage, especially in high-flow cases. Based on over two decades of institutional experience with 6,221 EEA procedures, this study aims to categorize and evaluate standardized reconstruction strategies based on intraoperative CSF flow rates in order to optimize outcomes and reduce postoperative complications.

Purely endoscopic endonasal resection of extracranial trigeminal schwannomas: a descriptive systematic review and institutional case series.

Background: Trigeminal schwannomas (TSs) are uncommon, benign tumors that arise from the trigeminal nerve. They can spread to the middle cranial fossa, posterior fossa, and extracranially (pterygopalatine fossa (PPF), infratemporal fossa, orbita). Among these, extracranial involvement is the least frequent.

Understanding the impact of multimorbidity, medications and frailty on zoledronic acid efficacy in treating osteoporosis among older adults.

Aims: This study investigates the interplay between drug effects, multimorbidity, frailty and comprehensive geriatric evaluation on zoledronic acid (ZA) treatment success in osteoporosis (OP), particularly among frail, older adults, a group often excluded from research.

Methods: In this retrospective cohort study, a retrospective analysis of 156 OP-treatment-naïve geriatric outpatients who received their first ZA treatment was conducted. Bone mineral density (BMD) and T-scores in the lumbar, femoral neck and total femur regions were assessed using dual-energy X-ray absorptiometry and patients' fall history was assessed.

Skin in the game: a review of computational models of the skin.

With the vast advances in computing technology, computational (or in silico) modelling has emerged as a transformative tool in dermatology. These findings can provide novel insights into complex biological processes and aid in the development of innovative therapeutic and regenerative strategies for the skin. Modelling combines experimental data and knowledge across multiple disciplines, serving as a common framework to elucidate the workings of the skin.

Long-term retinal microvascular alterations after endoscopic endonasal surgery in patients with sellar region tumors.

Aim: To evaluate retinal microcirculation changes at the 3 and 12 months following endoscopic endonasal surgery in patients with sellar region tumors using optical coherence tomography angiography (OCT-A).

Methods: This prospective longitudinal observational study included 78 eyes of 39 patients with sellar tumors and 78 eyes of 39 age- and gender-matched healthy controls. Standard automated perimetry and OCT-A were performed preoperatively and at 3- and 12-month follow-ups.