Peripheral monocyte transcriptional signatures of inflammation and oxidative stress in Parkinson's disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra, which is accompanied by immune dysfunction and chronic inflammation. Peripheral monocytes, key players in systemic inflammation, cross the blood-brain barrier and alter PD etiology and progression. To define the role of peripheral monocytes, cross-sectional studies of RNA transcripts isolated from PD monocytes were compared with age- and sex-matched control monocytes.

HSN-helping in mental distress: a new emotion focused psychological first aid program.

Psychological first aid programs aim to train lay people to help others who are experiencing a mental health crisis or developing mental health problems. The current article introduces the new German psychological first aid training program HSN. The acronym HSN stands for "Helfen in Seelischer Not" (helping in mental distress) but also for the action chain "hear, speak, network.

Low-dose interleukin-2 in patients with mild to moderate Alzheimer's disease: a randomized clinical trial.

Background: We previously documented that regulatory T cells (Tregs) immunomodulatory mechanisms are compromised in Alzheimer's disease (AD), shifting the immune system toward a pro-inflammatory response. However, Tregs are a potentially restorable therapeutic target in AD. In this study, we evaluated the safety and efficacy of two dosing frequencies of low-dose Interleukin-2 (IL-2) in expanding Tregs to modify disease progression in AD individuals.

Hypertension Self-Management and Stroke Recovery Among Rural Adults in the Stroke Belt: A Mixed-Methods Study.

Limited knowledge exist on HTN-related knowledge and health behaviors among African American adult stroke survivors with hypertension condition living in rural Alabama. To address this gap, we conducted a small pilot study with a mixed methods design for needs assessment of stroke survivors with a hypertension condition living in rural areas of Alabama. We followed the community engagement strategy approach to conduct our study.

Pneumonitis after chemoradiation followed by durvalumab for locally advanced lung cancer: predictors and effect on survival.

Introduction: We hypothesized that pneumonitis during Pacific protocol (PDP) contributes to poor outcomes in patients with locally advanced non-small cell lung cancer (LANSCLC) treated with chemoradiation (ChRT) and durvalumab.

Methods: We analysed cases with LANSCLC extracted from a single academic institution database to identify patient, tumour, and treatment characteristics predicting for development of PDP and its effect on oncologic outcomes.

Results: Our database review identified 119 patients with LANSCLC that were treated with ChRT and durvalumab.