Association between Trust of Researchers and Willingness to Participate in Alzheimer's Disease Biomarker Research.

Introduction: The study examined the relationship between trust of researchers in research naïve participants, including those at higher risk, and interest in Alzheimer's disease and related dementia (ADRD) biomarker research participation.

Methods: A cohort of 399 community-dwelling older adults completed a survey about their trust of researchers and interest in participating in ADRD biomarker research.

Results: After controlling for sociodemographics and knowledge of ADRD, higher trust of researchers was associated with lower levels of hesitancy to participate in ADRD biomarker and neuroimaging studies ( < 0.

International Consensus Guidelines for the Conduct and Reporting of CAR T-Cell Clinical Trials in AML.

Early clinical experience with the use of chimeric antigen receptor (CAR)-T cell therapies for patients with acute myeloid leukemia (AML) has been beset by high rates of toxicities and low rates of response. We convened an international workshop with the goal of bringing investigators in the field of AML-directed CAR-T cell therapy together to facilitate discussion of roadblocks and to brainstorm potential solutions. Based on discussions at the workshop, it was evident (i) that treating and targeting AML with CAR-T cells is associated with unique clinical challenges, and (ii) that variability in clinical trial design, definitions of toxicities, correlative data collection, and reporting methods hinders the field's ability to compare study outcomes and to develop best practices.

A remotely-delivered weight management service to support existing obesity services in the UK National Health Service: Preliminary findings from an early-stage service evaluation.

Background: Specialist weight management services (SWMS) in the UK National Health Service (NHS) face long waiting lists and limited resources. Remotely-delivered SWMSs may support existing NHS services to increase access to treatment for patients living with obesity, however evidence of remotely-delivered services working to support NHS SWMSs in practice remains limited.

Objective: This service evaluation explored the potential effectiveness, feasibility and acceptability of Second Nature's remotely-delivered SWMS for adults living with obesity referred from existing NHS SWMSs.

Evaluation of Diet Quality, Physical Health, and Mental Health Baseline Data from a Wellness Intervention for Individuals Living in Transitional Housing.

: The aim of this study was to evaluate baseline health measurements among transitional housing residents ( = 29) participating in an 8-week pilot wellness intervention. : Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, and health-related perceptions. Researchers analyzed data using descriptive statistics and conventional content analysis.

Identification of miRNA Biomarkers Associated With Staphylococcal Musculoskeletal Infections.

Musculoskeletal infections (MSKIs) pose significant challenges in orthopedic surgery. These infections are often caused by Staphylococcus aureus and S. epidermidis.