Renal perfusion pressure: role and implications in critical illness.

The pressure-flow relationship is fundamental to circulatory hemodynamics of any organ. In the kidney, renal perfusion pressure (RPP), defined as the gradient between mean arterial pressure and renal venous pressure or mean systemic filling pressure, serves as the principal driving pressure for renal blood flow (RBF). This concept recognizes that both arterial hypotension and venous congestion can reduce the pressure gradient for renal perfusion, potentially contributing to renal dysfunction or acute kidney injury (AKI).

Unexplained fall and fatal head injury: Forensic implications of neurocysticercosis.

Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system (CNS) by the larval stage of Taenia solium. We present a case of an unresponsive 32-year-old man who was found outside a steel manufacturing factory, taken to the emergency department by the police, and then declared dead. There were no external injuries apparent at autopsy; however, internal examination revealed a basilar skull fracture, subarachnoid hemorrhage, and multiple cystic lesions in the brain.

Nanoparticles for mRNA-based cancer immunotherapy.

The emergence of mRNA-based cancer immunotherapy has transformed the avenue of cancer treatment, offering an innovative strategy that leverages the body's immune system to identify and eradicate tumor cells selectively. Effective delivery of mRNA to specific organs and cells is limited by its instability, low cellular uptake efficiency, and degradation during extracellular transport and endosomal escape. Significant advancements in nanoparticle design have driven the rapid progress of mRNA-based immunotherapies.

Ameliorating Gastrointestinal Symptoms in Children With Autism Spectrum Disorder by Modulating the Gut Microbiota: A Systematic Review and Meta-Analysis.

Children with autism spectrum disorder (ASD) exhibit a high prevalence (55%) of gastrointestinal symptoms (GISs) and gut dysbiosis. Most studies involving children with ASD have focused on behavioral symptoms but not GISs. This systematic review and meta-analysis investigated the effects of gut microbiota-modulating interventions (GMMIs) on GISs and gut microbial composition in children with ASD.