Publications by authors named "R A Zarate"
HMGB1 B-Box Domain Associates Promote Protein-Polyelectrolyte Interactions.
J Phys Chem B
September 2025
HMGB1, a nuclear DNA-binding protein, can be secreted by activated immune cells or passively released from damaged cells. In such cases, HMGB1 functions as an alarmin that activates the immune system. Excessive inflammation may lead to pathogenesis, whereas this response can be dampened by polyanion binding, which impedes further receptor recognition.
View Article and Find Full Text PDFNeighborhood disadvantage and the back-to-school epidemic of viral-associated asthma exacerbations.
J Allergy Clin Immunol
July 2025
Background: Rates of viral-associated asthma exacerbations typically increase when children return to school after the summer holiday. The effect of neighborhood disadvantage on this back-to-school increase in viral-associated asthma exacerbations is unknown.
Objective: We aimed to evaluate the effect of neighborhood disadvantage on the back-to-school increase in asthma-related emergency department (ED) visits.
Impact of Radiation Dose on the Survival of Patients With Non-small Cell Lung Cancer Treated With Palliative Intent: Results of a Multicenter Prospective Study.
Anticancer Res
December 2024
Background/aim: Many patients with non-small cell lung cancer (NSCLC) receive palliative radiotherapy (RT). Several factors were analyzed to aid in prescribing an optimal treatment for these patients.
Patients And Methods: This prospective observational multicenter study investigated several potential factors for associations with overall survival (OS) in 61 patients with NSCLC receiving palliative RT with or without chemotherapy (CT).
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.
Neighborhood-level variability in asthma-related emergency department visits in Central Texas.
J Allergy Clin Immunol
October 2024
Background: The extent to which incidence rates of asthma-related emergency department (ED) visits vary from neighborhood to neighborhood and predictors of neighborhood-level asthma ED visit burden are not well understood.
Objective: We aimed to describe the census tract-level spatial distribution of asthma-related ED visits in Central Texas and identify neighborhood-level characteristics that explain variability in neighborhood-level asthma ED visit rates.
Methods: Conditional autoregressive models were used to examine the spatial distribution of asthma-related ED visit incidence rates across census tracts in Travis County, Texas, and assess the contribution of census tract characteristics to their distribution.