Synopsis of recent research by authors named "Parmit K Singh"
- Parmit K Singh's recent research focuses on understanding the mechanisms by which HIV-1 exploits host cellular factors during its infection process, particularly through the roles of CPSF6 and LEDGF in nuclear entry and viral DNA integration.
- Key findings demonstrate that HIV-1 integrates preferentially into transcriptionally active chromatin, utilizing various host proteins that mediate this process, including the interaction of CPSF6 with HIV-1 capsid proteins and the influence of chromatin structure on integration sites.
- Singh's studies also reveal the significance of liquid-liquid phase separation and prion-like domains in CPSF6 during HIV-1 infection, as well as the impact of different host proteins on the efficiency and mechanisms of HIV-1 integration into the host genome.
