Impact of race-based customization on detection of fetal growth restriction.

Objective: Fetal growth standards determine which fetuses are diagnosed with fetal growth restriction (FGR) and become candidates for enhanced fetal monitoring. Given the existence of race-based differences in fetal and neonatal weights, we sought to determine the impact of race-based customization of fetal growth curves on the antenatal detection of FGR.

Methods: This was a retrospective cohort study of 8731 individuals who identified as either White or Black and delivered a liveborn singleton at Magee-Womens Hospital (MWH), Pittsburgh, PA, USA, between January 2003 and January 2013, with at least one sonographic measurement of estimated fetal weight (EFW) taken at 23-41 weeks' gestation.

IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas.

Malignant B cells rely on B cell receptor (BCR) signals for their survival and growth. Besides the Immunoglobulin M (IgM) BCR, lymphoma cells can also express non-IgM (IgG) BCRs; however, the role of IgG BCRs in malignant B cell is not well understood. Here, we report poorer disease outcomes in diffuse large B cell lymphoma (DLBCL) expressing high IgM versus those expressing IgG1.

Multicentric validation of the PathoDetect™ MTB RIF & INH assay for simultaneous detection of Mycobacterium tuberculosis, & drug resistance to rifampicin & isoniazid in presumptive pulmonary tuberculosis & drug-resistant TB patients.

Background & objectives Tuberculosis (TB) remains a major global health concern, with India accounting for 26 per cent of the global burden. Despite advances, access to rapid molecular diagnostics is limited, and the assays currently used in National TB Elimination Programme (NTEP) do not detect isoniazid (INH) resistance upfront. PathoDetect™ MTB RIF & INH is an indigenous closed-system assay that simultaneously detects Mycobacterium tuberculosis (MTB) and resistance to rifampicin (RIF) and INH.

How Do Hepatocyte MicroRNAs Play a Role in Hepatitis C Virus Replication and Pathogenesis? Emerging Hypotheses and Strategies for MicroRNA Therapeutics and Drug Development.

Hepatitis C virus (HCV) is a major global health burden affecting millions worldwide. A deeper understanding of and theories on the mechanisms of HCV replication and pathogenesis would bode well for diagnostics and therapeutics innovation. For example, HCV is known to modulate the host genes (e.

Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI: A Meta-Analysis of Randomized Controlled Trials.

Background: Disparities in cardiovascular disease presentation and outcomes between men and women are well-documented. While intravascular imaging (IVI) improves percutaneous coronary intervention (PCI) outcomes, its potential sex-specific benefits remain unclear.

Objectives: The purpose of this study was to determine sex differences in adverse cardiovascular events in coronary artery disease patients undergoing PCI with IVI guidance vs angiography alone.