Lysine demethylase 4A is a centrosome-associated protein required for centrosome integrity and genomic stability.

Centrosomes play a fundamental role in nucleating and organizing microtubules in the cell and are vital for faithful chromosome segregation and maintenance of genomic stability. Loss of structural or functional integrity of centrosomes causes genomic instability and is a driver of oncogenesis. Here we identify lysine demethylase 4A (KDM4A), an epigenetic 'eraser' of chromatin methyl marks, as a centrosome-localized protein, visualized at the nanometer-scale resolution.

Differential impacts of various plant growth-promoting and osmotic tolerant bacterial strains on proline and sugar accumulation to enhance stress adaptations in tea plants.

Drought stress poses a severe threat to tea plantations globally, leading to a significant reduction in yields. Use of plant growth-promoting bacteria (PGPB) has emerged as a promising strategy to alleviate the detrimental effects of water stress. This study investigates nine distinct bacterial strains, isolated from a drought-prone region in North-East India, for their plant growth-promoting (PGP) traits and their ability to mitigate osmotic stress.

Enhancement of optical limiting activity of para-aminobenzoic acid using silver nanoparticles.

An extensive study on the laser power limiting behavior of para-aminobenzoic acid (PABA) combined with silver nanoparticles (PABA + AgNPs) was done and reported in this article. The XRD spectra for PABA + AgNPs confirm its crystalline structure. The absorption spectra of AgNPs and PABA + AgNPs indicate complete stability of the samples.

Influence of Crowding Agents on the Small GTPase Rab2B: Stability Consideration and Intermediate Formation.

This work investigates the thermal and chemical denaturation of recombinant Rab2B in the absence and presence of varying concentrations of denaturant (urea) under crowded environments using the synthetic crowders PEG 8 (polyethylene glycol, MW of 8 kDa) and Ficoll 70 (MW of 70 kDa). Rab2B plays an important role in vesicle trafficking, and more specifically, it is crucial in maintaining the integrity of the Golgi morphology. Our findings demonstrate that increasing concentrations of urea lead to a decrease in both the thermal and chemical stability of Rab2B in a crowder-dependent manner.