Outcome-guided spike-and-slab Lasso Biclustering: A Novel Approach for Enhancing Biclustering Techniques for Gene Expression Analysis.

Biclustering has gained interest in gene expression data analysis due to its ability to identify groups of samples that exhibit similar behaviour in specific subsets of genes (or vice versa), in contrast to traditional clustering methods that classify samples based on all genes. Despite advances, biclustering remains a challenging problem, even with cutting-edge methodologies. This paper introduces an extension of the recently proposed Spike-and-Slab Lasso Biclustering (SSLB) algorithm, termed Outcome-Guided SSLB (OG-SSLB), aimed at enhancing the identification of biclusters in gene expression analysis.

Evolution of the tumor immune landscape during treatment with tebentafusp, a T cell receptor-CD3 bispecific.

Metastatic uveal melanoma is an aggressive disease with poor outcome, which is refractory to immune checkpoint inhibitors. A T cell receptor (TCR)-based CD3 bispecific, tebentafusp, delivers clinical benefit in patients with metastatic uveal melanoma. Understanding the molecular basis for the anti-tumor activity of tebentafusp in an indication where checkpoint inhibitors are ineffective could aid in identification of other solid tumor indications where CD3 bispecifics may serve an unmet need.

VICatMix: variational Bayesian clustering and variable selection for discrete biomedical data.

Summary: Effective clustering of biomedical data is crucial in precision medicine, enabling accurate stratification of patients or samples. However, the growth in availability of high-dimensional categorical data, including 'omics data, necessitates computationally efficient clustering algorithms. We present VICatMix, a variational Bayesian finite mixture model designed for the clustering of categorical data.

The Relations Among Anxiety, Movie-Watching, and in-Scanner Motion.

Movie-watching fMRI has emerged as a theoretically viable platform for studying neurobiological substrates of affective states and emotional disorders such as pathological anxiety. However, using anxiety-inducing movie clips to probe relevant states impacted by psychopathology could risk exacerbating in-scanner movement, decreasing signal quality/quantity and thus statistical power. This could be especially problematic in target populations such as children who typically move more in the scanner.

New from opposite ends of the world.

The is a group of ancient fungi with global distribution. In the current study we accessed mucoralean fungi isolated from two countries on opposite sides of the Earth and in different hemispheres: South Korea and Brazil. isolates were obtained from freshwater, soil, invertebrates, and fruit seeds and identified using phenotypic techniques combined with the DNA sequence data.