Is every pancreatic cancer patient a palliative care patient?

ancreatic cancer is an aggressive disease and often presents at an advanced stage with no curative options. The disease is often characterized by rapid progression, limited or short-lived responsiveness to standard therapies, and a profound impact on patients' quality of life. Despite advances in targeted therapies and immunotherapy, curative outcomes remain elusive for the majority of patients with advanced or high-grade disease with a 5-year survival rate of less than 10%.

Recent developments and innovative application of propolis in the food industry: a natural preservative from honeybee waste.

Unlabelled: Propolis, or bee glue, is a resinous substance produced by honeybees from plant resins, rich in bioactive compounds with antimicrobial, antioxidant, anti-cancer, anti-inflammatory, and anti-cavity properties. These qualities make it a valuable natural preservative in the food industry, extending shelf life and preventing spoilage. Propolis has gained attention as an alternative to synthetic preservatives.

Association of deep learning-derived histologic features of placental chorionic villi with maternal and infant characteristics in the New Hampshire birth cohort study.

Introduction: Quantification of placental histopathological structures is challenging due to a limited number of perinatal pathologists, constrained resources, and subjective assessments prone to variability. Objective standardization of placental structure is crucial for easing the burden on pathologists, gaining deeper insights into placental growth and adaptation, and ultimately improving maternal and fetal health outcomes.

Methods: Leveraging advancements in deep-learning segmentation, we developed an automated approach to detect over 9 million placenta chorionic villi from 1531 term placental whole slide images from the New Hampshire Birth Cohort Study.

Role of transcutaneous electric nerve stimulation (TENS) in the mandibular third molar surgery-a clinical study.

Objectives: Surgical extraction of the impacted mandibular third molar has undesirable side effects such as pain, swelling, bleeding, alveolar osteitis, and trismus. This study evaluates the efficiency of transcutaneous electronic nerve stimulation (TENS) in the control of perioperative pain and postoperative oedema & trismus after the surgical extraction of impacted mandibular 3rd molars.

Study Design: A prospective, comparative, randomized, double-blind controlled clinical study was conducted on 23 patients requiring surgical extraction of bilateral impacted mandibular third molars.

Controversies and conundrums in pachychoroid spectrum disorders: A structured diagnostic approach.

The term pachychoroid, derived from the Greek word pachy meaning "thick," refers to a choroidal phenotype characterized by increased choroidal thickness, dilated outer choroidal vessels (pachyvessels), and attenuation of the overlying Sattler layer and choriocapillaris. Initially recognized in central serous chorioretinopathy, this phenotype is now acknowledged as the underlying pathophysiological basis for a broader spectrum of retinal disorders, including pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy, focal choroidal excavation, peripapillary pachychoroid syndrome, pachydrusen and pachychoroid geographic atrophy. Collectively referred to as the pachychoroid disease spectrum, these entities share common features such as structural choroidal remodeling, choroidal vascular hyperpermeability, and outer retinal or retinal pigment epithelial changes.