Treatment de-escalation for metastatic good-risk seminoma with carboplatin AUC10: predictive factors and patterns of relapse.

Background: We have previously demonstrated that carboplatin AUC10 is a viable alternative to cisplatin-based combination chemotherapy for patients with metastatic good-risk seminoma. The International Germ Cell Cancer Collaborative Group (IGCCCG) update identified lactate dehydrogenase (LDH) as an adverse prognostic marker in those receiving cisplatin-based therapies but its relevance in patients treated with carboplatin AUC10 is unknown.

Objectives: To update survival outcomes of patients treated with carboplatin AUC10, explore patterns of treatment relapse and determine the impact of clinical and biochemical factors on oncological outcomes.

Impact of Thrombopoietin Receptor Agonists on Platelet Transfusion Requirements in Myelodysplastic Syndromes: An Updated Systematic Review and Meta-Analysis.

Background: Thrombocytopenia in myelodysplastic syndromes (MDS) is associated with bleeding complications, transfusion dependence, and reduced quality of life. While platelet transfusions remain standard care, they carry limitations including short durability, alloimmunization, and infection risk. Thrombopoietin receptor agonists (TPO-RAs), such as eltrombopagand romiplostim, have emerged as potential alternatives, but their efficacy and safety remain incompletely defined.

Synergistic insecticidal effects of zinc-loaded zeolite nanoparticles combined with essential oils against Callosobruchus maculatus.

Callosobruchus maculatus (F.) is a serious pest that causes post-harvest losses, which is a threat to global food security, therefore there is need to develop sustainable pest management strategies. This study investigates the synergistic insecticidal effects of zinc-loaded zeolite nanoparticles in combination with essential oils from Rosmarinus officinalis (L.

Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction.

Numerous therapeutic and culinary species produce scopoletin, a coumarin that is essential for treating a wide range of illnesses as a curative and chemopreventive agent. Globally, chronic illnesses are regarded as a major public health concern. Atypical regulation of various signalling pathways is the primary cause of most of these illnesses, which include cancer, as well as cardiovascular, metabolic, and neurological disorders.

Clinical, biochemical, and molecular characteristics of Sanfilippo a syndrome (MPS IIIA) in a cohort of Egyptian patients.

Background: Lysosomal storage diseases (LSDs) is a large group of genetically heterogeneous inherited metabolic disorders that affect the functions of the lysosomes in various human tissues. Mucopolysaccharidosis type IIIA (MPSIIIA), Sanflippo syndrome A, is a rare autosomal recessive LSD caused by biallelic variants in the SGSH gene, codes for the lysosomal enzyme heparan-N-sulphatase. This study aimed to find out the SGSH mutational spectrum, clinical and biochemical characteristics in a cohort of MPS IIIA Egyptian patients.