Synopsis of recent research by authors named "Michael Sporn"
- Michael Sporn's recent research focuses on the development and evaluation of synthetic oleanane triterpenoids, like CDDO-2P-Im, which demonstrate significant anticancer properties by inducing apoptotic pathways through the unfolded protein response.
- He has extensively studied the Nrf2 signaling pathway, highlighting its protective role against radiation-induced oral mucositis and its implications in cancer prevention and treatment, particularly in the context of lung and breast cancers.
- Sporn's work emphasizes the potential of novel rexinoids and bromodomain inhibitors in cancer prevention, revealing their mechanisms in modulating immune responses and regulating gene expression critical for therapeutic efficacy against various malignancies.
