Pilot Study of Factors Influencing Engagement with an mHealth Intervention Among Teens with Eating Disorder Symptoms.

Purpose: The current pilot study examines engagement with and preliminary effectiveness of an mHealth intervention designed for teens with eating disorders (EDs) to delineate specific user characteristics associated with intervention engagement and the impact of this engagement on ED symptoms.

Methods: Teens 14-17 years old with or at high-risk for an ED were recruited from social media (n=29) and provided access to an mHealth intervention for 2 months. At baseline, participants were surveyed on ED and other mental health symptoms and demographics.

Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates.

Aim: This study evaluated the impact of retinal extracellular matrix (ECM) and key biomaterial substrates on the motility of transplantable retinal cells with genomic manipulation, using the therapeutic molecule, Topoisomerase II beta (Top2b), as a model.

Methods: Tests first applied in ovo electroporation to examine the effects of a pharmacological Top2b inhibitor (ICRF-193) on progenitor motility and development of embryonic retina. Complementary qRT-PCR tests measured changes in select cadherin molecules in response to treatment.

Clinical and Genetic Characterization of the Largest Cohort of Patients With D3 Limb-Girdle Muscular Dystrophy in an Isolated Uruguayan Population.

Background: Limb-girdle muscular dystrophies (LGMD) are a heterogeneous group of genetic disorders characterized by progressive proximal weakness. LGMD D3 is an extremely rare autosomal dominant myopathy caused by pathogenic variants in the HNRNPDL gene encoding a protein related to RNA processing. To date, only six countries and seven families have been reported worldwide: Brazil, China and Italy with the pathogenic variant c.

Using Biocontrol Fungi to Control Helminthosis in Wild Animals: An Innovative Proposal for the Health and Conservation of Species.

Helminth parasites of wild animals represent a major threat to the health of these animals, leading to significant losses in performance, health, and zoonotic implications. In some zoos, anthelmintics have traditionally been used to control these parasites, many of which are also zoonotic. Other actions, such as the removal of organic waste, have also been adopted.

The R-loop grammar predicts R-loop formation under different topological constraints.

R-loops are transient three-stranded nucleic acids that form during transcription when the nascent RNA hybridizes with the template DNA, freeing the non-template strand of the DNA. There is growing evidence that R-loops play important roles in physiological processes such as the regulation of gene expression, and that they contribute to chromosomal instability and disease. It is known that R-loop formation is influenced by both the sequence and the topology of the DNA substrate, but many questions remain about how R-loops form and the three-dimensional structures that they adopt.