Reconnecting the roots of hydrogen sulfide (HS) with medicinal chemistry: Lessons accomplished and challenges so far.

Previously known for its unpleasant odour and mortality in elevated concentrations, hydrogen sulfide (HS) is currently considered a complex molecule having significant physiological advantages. After nitric oxide (NO) and carbon monoxide (CO), HS is regarded as the third endogenous gasotransmitter, performing many biological functions in the human body. The essential functions include but are not limited to regulating inflammation, maintaining the redox potential, cellular signalling, and metabolic processes.

Design and synthesis of new 1,4-naphthoquinones appended sulfenylated thiazoles as cyclooxygenase II inhibitors: Exploring the utility in the development of anticancer agents.

Clinical evaluations revealed the direct role of chronic inflammation in cancer progression. The cyclooxygenase (COX) pathway is particularly important among the various pathways involved in inflammation. There are two COX isoforms: COX-1 and COX-2.

Nanotechnology Assisted Drug Delivery Strategies for Chemotherapy: Recent Advances and Future Prospects.

In pursuit of the treatment of cancer, nanotechnology engineering has emerged as the simplest and most effective means, with the potential to deliver antitumor chemotherapeutics at the targeted site. Employing nanotechnology for drug delivery provides diverse nanosize particles ranging from one to a thousand nanometers. Reduced size improves drug bioavailability by increasing drug diffusion and decreasing the efflux rate.

Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ aggregation inhibition in Alzheimer's disease.

Current therapeutic regimens approved to treat Alzheimer's disease (AD) provide symptomatic relief by replenishing the acetylcholine levels in the brain by inhibiting AChE. However, these drugs don't halt or slow down the progression of Alzheimer's disease, which remains a major challenge. Evidence suggests a significant increase in BuChE activity with a decrease in AChE activity as the AD progresses along with the Aβ aggregation.

An indolium inspired portable colorimetric sensor for cyanide recognition in environmental samples with smartphone integration.

Cyanide is a highly hazardous and fast-acting blood agent widely used in various industries, making its monitoring crucial due to its severe impact on living organisms. Considering this, we had developed a novel indolium based low-cost and portable sensor for the colorimetric and fluorogenic detection of cyanide ions. The probe displayed a distinct visual color change and selectively exhibits a fluorogenic "turn-off" response to cyanide ions in pure aqueous medium.