Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice.

Extremely short telomeres cause bone marrow failure in telomere biology disorder (TBDs) patients. Here, we employed the recently developed 'Telomouse' with human-length telomeres resulting from a single amino acid substitution in the helicase Rtel1 ( ) to determine the effects of the short telomeres on the bone marrow and hematopoiesis. Under homeostatic conditions, Telomice have notably short telomeres but normal hematopoiesis.

Detection of Rat Lungworms in Invasive Mollusks, Georgia, USA, 2024.

The rat lungworm, Angiostrongylus cantonensis, is an invasive, zoonotic parasite that can cause severe disease in humans. We collected A. cantonensis larvae from 2 host species, invasive apple and mystery snails, from bodies of water in Georgia, USA.

Assessing the impact of day programs on individuals living with dementia and their family/friend caregivers (AIDA-DemCare): protocol of a prospective cohort study combined with a qualitative evaluation.

Background: Persons with dementia, their family/friend caregivers, and health systems agree that the preferred place of dementia care is a person's home. Health systems have struggled to provide sufficient community-based dementia care supports, negatively affecting the health and well-being of persons with dementia and their caregivers. Therefore, dementia care and support of dementia caregivers are critical public health priorities.

Neural Control of Goblet Cell Function in the Gastrointestinal Tract.

The mucus layer is an essential physical barrier that protects and lubricates mucosal surfaces in the body. The semi-permeable nature of the mucus layer limits bacterial interactions with the epithelium, while allowing nutrient absorption. Goblet cells (GCs) are specialized epithelial cells with a classical role to synthesize and secrete mucus to maintain the mucus layer.

Frameworks used to evaluate community-based rehabilitation interventions: A scoping review.

Background: Community-based rehabilitation (CBR) interventions are important for improving the well-being of people with disabilities. However, there is no universally accepted framework for evaluating these interventions, which limits their effectiveness and integration into policy.

Objectives: To explore theoretical frameworks used in evaluating CBR interventions, assessing their suitability, context-specific applicability and cultural relevance.