Production of apoferritin/chitosan complex by Maillard reaction as a promising platform to enhance pDNA delivery.

Ferritin is a shell-like carrier protein with an 8 nm diameter cavity that naturally provides a space for encapsulating food and drug components. In the absence of iron atoms bound to this protein, it is called apoferritin, the form used in this study. However, its vulnerability to environmental conditions when used alone warrants further investigation.

Isolating design variables by assessing the impact of cross-section geometry on the mechanical performance of nickel-titanium rotary instruments: a comparative in vitro study.

Objectives: This study aimed to assess the effect of cross-section geometry on the mechanical properties of nickel-titanium (NiTi) instruments by comparing two instruments with identical tip size, taper, and thermal treatment but differing in cross-section design.

Methods: One hundred four NiTi rotary instruments, being S-shaped and triangular cross-section, manufactured with Blueish thermal treatment, were tested (n = 52 per group). Differential scanning calorimetry was employed, and the metal mass volume and cross-section area were assessed.

Double-carbapenemase-producing Enterobacteriaceae: complete genome sequencing of isolates from hospitals in Paraguay, 2021.

Background: Motivation for the study. To generate knowledge about the current situation of antimicrobial resistance in Enterobacteriaceae using whole genome sequencing. Main findings.

MAIA platform for routine clinical testing: an artificial intelligence embryo selection tool developed to assist embryologists.

The need to reduce the number of embryos transferred in assisted reproductive care to prevent multiple gestations has led to a stronger emphasis on selecting embryos with the highest morphological quality. Although this evaluation has traditionally been performed by trained embryologists, the increasing use of time-lapse incubators has introduced a greater volume of data and subjectivity in decision-making. Artificial intelligence (AI)-based tools can support embryologists by offering objective, standardized embryo assessments.

Neuroinflammation in long COVID: the role of the Val16Ala polymorphism of SOD2 and cognitive impairment.

Long COVID (LC) includes persistent behavioral and cognitive deficits, impacting quality of life. Neuroinflammation plays a key role in these alterations, with genetic factors influencing susceptibility. The MnSOD Val16Ala SNP is associated with neuroinflammation and cognitive dysfunction, but its role in LC remains unclear.