Integrated 'omics analysis reveals human milk oligosaccharide biosynthesis programs in human lactocytes.

Human milk oligosaccharides (HMOs) are integral to infant health. Yet, their complex biosynthesis pathways in the mammary gland during lactation remain under-characterized. To address this knowledge gap, we performed integrated analyses of single-cell RNA-sequencing (scRNA-seq) datasets combined with select HMO concentration measures.

Does provable absence of barren plateaus imply classical simulability?

A large amount of effort has recently been put into understanding the barren plateau phenomenon. In this perspective article, we face the increasingly loud elephant in the room and ask a question that has been hinted at by many but not explicitly addressed: Can the structure that allows one to avoid barren plateaus also be leveraged to efficiently simulate the loss classically? We collect evidence-on a case-by-case basis-that many commonly used models whose loss landscapes avoid barren plateaus can also admit classical simulation, provided that one can collect some classical data from quantum devices during an initial data acquisition phase. This follows from the observation that barren plateaus result from a curse of dimensionality, and that current approaches for solving them end up encoding the problem into some small, classically simulable, subspaces.

Association of Surgeons' Male or Female Gender and Urgent/Emergent Add-on Cases Wait Time: A Multicentric Hospital Registry Trial.

Objective: This study aimed to evaluate whether wait times for urgent or emergent operations cases differ between female and male attending surgeons.

Summary Background Data: Patients treated by female surgeons experience lower complication rates compared to those treated by male surgeons. The impact of surgeon gender on wait times remains underexplored.

The Relationship of Alzheimer's Disease and Related Dementias Blood-Based Biomarkers and Informant-Reported Neuropsychiatric Symptoms Differs by Informant Type in Older Adults Without Dementia.

Objectives: In a sample of community-dwelling older adults, we examined the association of Alzheimer's Disease and Related Dementias (AD/ADRD) blood-based biomarkers (BBMs) and neuropsychiatric symptoms (NPS) and whether informant type (i.e., spouse vs.

Observation of the Very Rare Σ^{+}→pμ^{+}μ^{-} Decay.

The first observation of the Σ^{+}→pμ^{+}μ^{-} decay is reported with high significance using proton-proton collision data, corresponding to an integrated luminosity of 5.4  fb^{-1}, collected with the LHCb detector at a center-of-mass energy of 13 TeV. A yield of 237±16  Σ^{+}→pμ^{+}μ^{-} decays is obtained, where the uncertainty is statistical only.