Bycatch survival of shortfin mako sharks (Isurus oxyrinchus) in the U.S. Atlantic pelagic longline fishery.

Severe population declines of shortfin mako sharks (Isurus oxyrinchus) in the Atlantic Ocean have led to the implementation of conservation measures, notably fishing retention bans and live-release regulations, aimed at substantially reducing fishing mortality to allow stock recovery. While retention bans can eliminate harvest mortality, their effectiveness can be reduced if survival of sharks encountered as bycatch and not retained is low. We quantified at-vessel survival (AVS) and post-release survival (PRS) and estimated overall bycatch survival probability of mako sharks for the U.

Two-tiered newborn screening for Infantile Krabbe disease allows for timely treatment initiation and avoids false positive results.

Purpose: Infantile Krabbe disease (IKD) is a severe, progressive neurological disorder that was recently added to the Recommended Uniform Screening Panel in the US. IKD is a critical condition that requires a hematopoietic stem cell transplant (HSCT) preferably by 30 days of age. This study examines if the two-tier newborn screening (NBS) strategy (psychosine (PSY) analysis when enzyme activity is low) causes clinically relevant delays compared with PSY measured at a first clinical follow up visit.

Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients-Protocol for a Delphi Study.

Intubated critically ill patients are susceptible to secretion accumulation because of compromised airway clearance. Various airway clearance interventions are employed to prevent complications arising from mucus retention. This Delphi study aims to collect global opinions in an international expert panel of ICU professionals on the usefulness of these various airway clearance interventions.

Examining the Effect of an Anion-Binding Reagent on the Structure of Deprotonated Leucine Enkephalin Using Cryogenic-Ion Infrared Action Spectroscopy.

Biomolecular systems feature a complex interaction network comprising numerous intra- and intermolecular interactions. By isolating biomolecules under vacuum conditions, the intricate balance between specific interaction motifs can be characterized with precise control over conditions. In this study, we apply cryogenic-ion infrared action spectroscopy and electronic structure methods to examine the structural changes in the deprotonated form of the model peptide leucine enkephalin (YGGFL) upon complexation with diserinol isophthalamide (DIP), an anion-binding reagent.

Brain protective ventilation in acute brain injury patients with use of fully automated ventilation (BRAVE): A cross-over clinical trial.

Background: Invasive ventilation can be challenging in acute brain injury (ABI) patients as partial pressure of carbon dioxide and oxygen need to be kept in precise optimal ranges while simultaneously applying lung-protective ventilation. Fully automated ventilation may be effective in achieving protective ventilation targets for brain and lung.

Objectives: To compare automated ventilation to conventional ventilation for ABI patients.