Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis.

Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.

Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.

The deadly drink: Nipah virus transmission through date palm sap, cultural practices and the evolution of behavioral interventions in Bangladesh over two decades.

Nipah virus (NiV) has emerged as a significant public health threat, with recurring outbreaks in Bangladesh often linked to the consumption of raw date palm sap contaminated by fruit bats (Pteropus species). Over the past two decades, substantial efforts have been made to understand the cultural context of sap consumption, promoting behavior change and developing interventions to prevent NiV spillover. Despite these efforts, achieving sustainable change in sap consumption practices remains challenging due to deep-seated cultural practices, community perceptions of sap consumption, habitual behaviors, limited awareness of health risks and economic barriers.

Overcoming standard-of-care resistance in glioblastoma using nanoparticle-based drug delivery targeting the autophagy pathway.

Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor in adults, characterized by rapid growth, diffuse infiltration, and a dismal prognosis. Despite aggressive treatment involving maximal surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy, therapeutic outcomes remain poor due to intrinsic and acquired resistance. Autophagy, a catabolic process that degrades damaged cellular components, plays a critical role in this resistance by enabling tumor cells to survive under metabolic, hypoxic, and therapeutic stress conditions.

Improving the thermoelectric power factor of PEDOT:PSS with 4,4'-bipyridine and LiBF .

Background: Thermoelectric (TE) materials can directly convert heat into electricity, which is beneficial for energy sustainability. Organic conducting polymers are TE materials that have drawn significant attention owing to different favorable properties, such as good processability, availability, flexibility, and intrinsically low thermal conductivity. Among the organic TEs, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is the most extensively investigated material because of its stability and high electrical conductivity.

Heterometallic Li/Zn, Li/Al and Li/In catalysts for -lactide ring-opening polymerisation: "ate" or "non-ate" pathways?

The ring-opening polymerisation (ROP) of lactide (LA) is an attractive route to produce aliphatic polyesters, with bimetallic catalysts displaying some of the highest catalyst activities to date. While a range of heterometallic catalysts have been reported to outperform their homometallic analogues, the origins of cooperativity are not always well understood. Previous studies indicate that the reaction pathways may differ for different metal heterocombinations, especially when an alkali metal is combined with zinc or aluminium.