Knowledge regarding helicobacter pylori infection among patients in hail region of Saudi Arabia.

Background: Helicobacter pylori () is a gram-negative widely prevalent bacterium that is known to cause chronic gastritis, peptic ulcer disease, gastric carcinoma, and gastric lymphoma. Considering peptic ulcer patients will experience chronic relapse, eliminating in this population is significant to prevent further relapses. The treatment should be based on the comorbidities and patient preferences.

Advances in Gene Therapy Clinical Trials for Hemophilia Care.

Gene therapy has revolutionized the therapeutic landscape for hemophilia A and B, offering the prospect for persistent endogenous production of coagulation factors VIII and IX. Recent advances in adeno-associated virus (AAV)-mediated gene transfer, particularly the approvals of valoctocogene roxaparvovec (Roctavian) and etranacogene dezaparvovec (Hemgenix), mark significant milestones in hemophilia care. This mini-review synthesizes emerging clinical data from phase I-III trials published between 2022 and 2025, emphasizing efficacy, durability, and immunogenicity profiles of leading AAV-based therapies.

PROTACs Targeting Molecular Targets in Triple-Negative Breast Cancer.

Triple-Negative Breast Cancer (TNBC) is defined as a type of breast cancer having the absence of estrogen, progesterone, and human epidermal growth factor receptors. So far, chemotherapeutic drugs and immunotherapy have several issues, such as being resistant to treatment, being harmful to the body, and not being fully effective. Lately, PROTACs have been discovered to assist in the breakdown of difficult-to-target oncoproteins employing the ubiquitin-proteasome system.

ICG-FA for Anastomotic Leak Prevention During Minimally Invasive Colorectal Surgery: A Meta-analysis.

Introduction: Anastomotic leakage is a serious complication after colorectal surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time perfusion assessment and may reduce leak rates; however, recent larger randomized clinical trials reported conflicting results. This meta-analysis aimed to clarify the effectiveness of ICG-FA in reducing anastomotic leakage and related complications following minimally invasive colorectal surgery.