Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.

Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for children and small animals. These systems often indiscriminately remove both harmful and protective antibodies, increasing the risk of complications such as life-threatening infections.

Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa-Impact of Oleogel-S10.

Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel.

Evaluation of Coronary Artery Disease and Ischemia by Cardiac Magnetic Resonance Imaging: Advances in Technology and Techniques.

This article explores the role of cardiac magnetic resonance (CMR) in the diagnosis and prognostication of ischemic heart disease. It highlights the diagnostic strengths of CMR rest and stress imaging techniques, including myocardial perfusion imaging, late gadolinium enhancement, and tissue characterization. This review also examines the utility of CMR in assessing common manifestations of ischemic heart disease, such as acute or chronic myocardial infarction, ventricular remodeling, and microvascular obstruction, as well as the added value of evaluating right ventricular function.

Brightening New Horizons: Luminescent Transition Metal Complexes in Optical Imaging and Theranostic Applications.

Small-molecule fluorescent probes have revolutionized fluorescence imaging in both biological research and clinical applications, allowing the exploration of intricate cellular processes and aiding disease diagnosis and treatment. Advances in the designs of molecular probes have led to the development of fluorescent theranostics that combine therapeutic and diagnostic modalities in a single platform. These dual-functional agents enable simultaneous disease diagnosis, treatment, and monitoring, representing an innovative approach to precision medicine.

Efficient MLC quality assurance using a virtual picket fence test in an MR-Linac.

Background: The Elekta Unity MR-Linac system integrates magnetic resonance imaging (MRI) with a linear accelerator (Linac) for adaptive radiation therapy. Traditional quality assurance (QA) methods for multi-leaf collimators (MLCs) face challenges in this system due to the magnetic field and limited field size of electronic portal imaging devices (EPID).

Purpose: This study aims to develop a 'virtual picket fence' test using machine log files to evaluate MLC performance in the Elekta Unity MR-Linac system, providing a more efficient and comprehensive QA method that overcomes the limitations of traditional approaches.