A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.

Background: Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α-synuclein (aSyn), are linked to rare familial forms of PD.

Objective: Our goal was to assess the clinical presentation and the biological effects of a novel K58N aSyn mutation identified in a patient with PD.

The last mile in onchocerciasis elimination: diagnostic challenges.

Global elimination of onchocerciasis is progressing. However, challenges persist in achieving elimination across all endemic regions, particularly in sub-Saharan Africa, due to diagnostic limitations and operational complexity in coendemic, resource-constrained settings. This review synthesizes the historical and programmatic trajectory of onchocerciasis control, outlines the WHO elimination framework and evaluates diagnostic tools across programmatic phases.

Membrane transporter genes predict chemoradiotherapy response in patients with cervical cancer.

Background: This study aimed to explore membrane transporter gene expression as a predictive biomarker of chemoradiotherapy response in cervical cancer. The differential expression of ATP1B3 and SLCO1B3 accurately classified patients as responders or non-responders with 90% accuracy, highlighting their potential for personalized treatment strategies.

Background: Two gene groups with contrasting expression profiles were identified.

Action-type mapping principles extend beyond evolutionarily conserved actions, even in people born without hands.

How are actions represented in the motor system? Although the sensorimotor system is broadly organized somatotopically, higher-level sensorimotor areas encode action-type information for reaching and grasping actions-regardless of the acting body part. Does the brain similarly support generalization across acting body parts for more evolutionarily recent actions, such as tool-use? We tested whether there is a body-part-independent action-type organization in sensorimotor areas by examining fMRI responses for tool-use actions that participants performed with their hands or feet. We additionally included individuals born without hands to test whether hand sensorimotor experience is necessary for the development of this action-type organization.

Metallic Nitride Microfluidic e-Tongue: A Novel Selective Approach for the Detection of Macronutrients in Soil.

The growing global demand for food requires optimizing agricultural practices and more rational use of natural resources without expanding cropping areas. Precision agriculture (PA) tools are essential for accurately applying fertilizers and herbicides, reducing costs, and avoiding environmental impacts. Standard macronutrient mapping methods are costly and time-consuming, limiting denser sampling collection in the field.