Primary Left Atrial Cardiopathy in Transthyretin Amyloidosis Cardiomyopathy by Multimodality Imaging: Implications for Thrombotic Events.

Background: Thrombotic event (TE) risk is high in transthyretin amyloid cardiomyopathy (ATTR-CM).

Objectives: The authors sought to explore left atrial (LA) remodeling in ATTR-CM and its association with TE risk in comparison to other phenotypes of left ventricular hypertrophy (LVH).

Methods: Subjects who underwent speckle tracking echocardiography, Tc-99m pyrophosphate scintigraphy, serum and urine immune electrophoresis, per registry protocol, were retrospectively identified (n = 405).

The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).

Structural, architectural, contractile, or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodelling has become a cornerstone diagnostic and prognostic marker. The structure and the function of the LA and left atrial appendage (LAA), which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillation, cardioembolism, heart failure, and mitral valve diseases.