Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood.

Objective: To examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males.

Methods: We studied 866 males with maternal pregnancy plasma measured for 15 PFAS, triclosan, and nine phthalate metabolites used as a proxy for prenatal exposure.

Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort.

Background: Phthalates are endocrine-disrupting chemicals that can dysregulate hormonal systems supporting female sexual function (eg, estrogen interference). Female sexual function is important for positive sexual expression, fertility, and well-being but remains understudied in the context of environmental toxicants to which females are ubiquitously exposed. Identifying environmental determinants of female sexual dysfunction can inform exposure-reduction strategies and clinical practice to improve sexual health.

A prospective study of hair dyes and uterine leiomyomata incidence in the study of environment, lifestyle, and fibroids.

Objective: To investigate associations between hair dye use and incident uterine leiomyomata (fibroids) among Black participants from the Study of Environment, Lifestyle, and Fibroids.

Design: Prospective cohort study.

Subjects: Reproductive-aged (26-39 years) individuals with an intact uterus residing in the Detroit, Michigan area (n = 868).