Prenatal hemoglobinopathy screening & prevention in India: A cross-sectional study.

Background & objectives India carries a significant burden of hemoglobinopathies, with beta-thalassemia and sickle cell disease (SCD) carrier rates ranging from 3-40 per cent by region. Despite the importance of universal screening, widespread prevention is challenging due to socio-cultural stigma, low awareness, and poor follow up. Sankalp's thalassemia prevention program used targeted prenatal screening rather than mass or cascade screening.

Granulocyte Colony-Stimulating Factor-Primed Bone Marrow Transplantation Experience in 350 Matched Sibling Donor Grafts for Severe Thalassemia.

Background: For matched related hematopoietic cell transplantation (HCT) for non-malignant diseases, most centers prefer bone marrow (BM) over peripheral blood stem cell (PBSC) grafts owing to increased risk of chronic graft-versus-host disease (GVHD-associated with the latter. BM generally entails delayed neutrophil and platelet recovery compared with PBSC transplants. Granulocyte colony-stimulating factor-primed bone marrow (G-BM) has been associated with faster hematologic recovery while retaining a decreased risk of GVHD.

Bone Marrow Quality Index: A Predictor of Acute Graft-versus-Host Disease in Hematopoietic Stem Cell Transplantation for Thalassemia.

Bone marrow (BM) continues to be the preferred source of stem cells in allogenic transplantation for nonmalignant disorders. Granulocyte colony-stimulating factor (G-CSF)-primed BM is associated with low rates of acute graft-versus-host disease (aGVHD) and allows reduced collection volumes while ensuring speedy engraftment. However, variability in BM harvest quality is a concern.

Musculoskeletal Disorders in Tyre Manufacturing Workers.

Background: Tyre manufacturing workers are at risk of developing WRMSDs as their job repeatedly involves elevated arm postures, lifting of tyres, pushing or pulling trolleys, trunk bending and twisting.

Aim: To assess WRMSDs in tyre manufacturing workers.

Methodology: This was an observational study involving 99 tyre manufacturing workers.

Design and development of safe gait prosthetic knee joint in India.

Context: The prosthetic technology in recent years has grown by leap and bounds. The most advanced gadgets like microprocessors are available worldwide at exorbitant costs. Developing countries have issues with terrain, access to services, and cost.