Principlistic Equality: The Relative Importance of the Four Principles Among Primary and Urgent Care Clinicians.

Principlistic equality, the idea that the four principles of bioethics should be considered as nonhierarchical in the abstract, is core to the original conception of principlism, but it is unclear whether clinicians endorse principlistic equality in practice. We surveyed 227 primary and urgent care clinicians (62.8% response rate), finding just over half of respondents (51.

Organizational Factors that Impact Trust in Healing Relationships: A Qualitative Study.

Background: Interpersonal trust is understood to be context-dependent, but literature describing patient-clinician trust has often ignored the impact of the local organization on this trust, neglecting the opportunity for clinicians and organizations to intervene to promote trust.

Objective: To explore the relationship between organizational factors and interpersonal trust between patients and their primary care clinicians.

Design: Qualitative study using semi-structured interviews of 40 patient-clinician dyads that were analyzed using a modified grounded theory approach.

Qualitative study of Black and Latino (a/e) caregiver participation on family-centered rounds.

Background: Family-centered rounds (FCR), multi-disciplinary rounds at bedside that involve the patient and family, has become the standard of care in pediatric hospitalizations. Caregiver participation on FCR improves shared-decision making and communication among providers, patients, and families. Evidence suggests Black and Latino (a/e) caregivers participate less during FCR than White caregivers, likely due to interpersonal and structural inequities, however contributing factors have not been adequately explored.

Experiences of recently diagnosed urban COVID-19 outpatients: A survey on patient worries, provider-patient interactions, and neutralizing monoclonal antibody treatment.

Background: COVID-19 patients have experienced worry, altered provider-patient interactions, and options to use novel treatments, initially with neutralizing monoclonal antibodies (mAbs). Limited research has been performed on these aspects of the COVID-19 outpatient experience.

Objective: This study aimed to evaluate the experiences of outpatients recently diagnosed with COVID-19, who were eligible for use of mAbs, during the diagnosis and treatment process based on sociodemographic and clinical factors.

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitative contribution of post-transcriptional mechanisms to cancer transcriptome dynamics remains unclear. Here, we systematically measured mRNA dynamics across diverse breast cancer models, revealing that mRNA stability significantly shapes gene expression variability.