Rewiring of cortical glucose metabolism fuels human brain cancer growth.

The brain avidly consumes glucose to fuel neurophysiology. Cancers of the brain, such as glioblastoma, relinquish physiological integrity and gain the ability to proliferate and invade healthy tissue. How brain cancers rewire glucose use to drive aggressive growth remains unclear.

Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer.

Purpose: We conducted a prospective, single-institution phase II trial to test the hypothesis that the addition of nivolumab to definitive chemoradiation would improve the progression-free survival (PFS) among patients with high-risk p16+ oropharyngeal squamous cell carcinoma (OPSCC).

Methods And Materials: Patients with previously-untreated locoregionally advanced, p16+ OPSCC (clinical T4/N3, matted lymph nodes, and/or retropharyngeal lymphadenopathy) were enrolled. Patients received a priming dose of nivolumab, concurrent nivolumab and chemoradiation (70 Gy to PTVhigh, 56 Gy to PTVlow, weekly carboplatin/paclitaxel), and 4 cycles of adjuvant nivolumab over 12 weeks.

Microplasma-Generated Plasma-Activated Water: A Coalescence of Ions and Free Radicals Facilitating Cancer Cell Death─Impact of Plasma-Forming Gases.

Plasma-activated solutions (PAS), a cocktail of ions and free radicals, have emerged as a therapeutic approach for cancer treatment in which reactive radicals in PAS have marked anticarcinogenic effects on cancer cells. In this context, the anticancer effects of plasma-activated water (PAW) generated using a microplasma device were evaluated with air, argon, and nitrogen as plasma-forming gases at treatment durations of 5-25 min (5 min intervals). Optical characterization revealed that air and nitrogen plasma harnessed nitrogen species, whereas argon and air plasma indicated OH and oxygen species.