Inhibitory potential of pentagalloyl glucose against efflux pumps in .

Antibiotic resistance in Gram-positive priority pathogens is mediated by a diverse set of mechanisms such as target protection, antibiotic inactivation, decreased uptake, antibiotic efflux, In , efflux pumps of the major facilitator superfamily (MFS) expel various antibiotics and multiple efflux pumps are activated upon antibiotic exposure. Efflux pump inhibitors (EPIs) that can act as antibiotic adjuvants are proposed to be promising solutions to tackle antibiotic resistance. In this study, screening of 17 967 phytochemical compounds from Indian medicinal plants (IMPPAT 2.

The impact of clinical audits on improving the effectiveness of type 2 diabetes mellitus (T2DM) CARE in primary health centers: A comprehensive pre-post analysis through multi-layered intervention [ICAE-DM CARE STUDY PROTOCOL].

Type 2 Diabetes Mellitus (T2DM) remains a global health challenge, with increasing prevalence in the Middle East, especially in Qatar. The Primary Health Care Corporation (PHCC) is the main provider of diabetes care in the country. Systematic evaluation through clinical audits provides a structured approach to identify gaps and improve clinical practices.

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells.

The functional significance of the interactions between proteins in living cells to form short-lived quaternary structures cannot be overemphasized. Yet, quaternary structure information is not captured by current methods; nor can those methods determine structure within living cells. The dynamic versatility, abundance, and functional diversity of G protein-coupled receptors (GPCRs) pose myriad challenges to existing technologies but also present these proteins as the ideal testbed for new technologies to investigate the complex inter-regulation of receptor-ligand, receptor-receptor, and receptor-downstream effector interfaces in living cells.

Impact of Multi-Disciplinary Team in Implementing Clinical Audit Recommendations to Improve Health Educators' Practice at Primary Care in Qatar.

Background: Health educators play a vital role in primary care by educating patients on the significance of maintaining good health and preventive measures, especially in the case of chronic illnesses. Evaluating the impact of their efforts is essential to ensure the delivery of high-quality patient care.

Method: A multi-layered process involves pre-intervention analysis of 180 health records, followed by a SWOT analysis to identify necessary interventions, facilitated by a multidisciplinary team to enhance the quality of practice.

Efficacy of Dapagliflozin + Sitagliptin + Metformin Versus Sitagliptin + Metformin in T2DM Inadequately Controlled on Metformin Monotherapy: A Multicentric Randomized Trial.

Introduction: A slower adoption rate of fixed dose combinations (FDC) in diabetes management is partly due to insufficient data. This study evaluates the safety and efficacy of an FDC of dapagliflozin + sitagliptin + metformin hydrochloride extended release (XR), compared to a dual FDC of sitagliptin + metformin hydrochloride XR among patients with type 2 diabetes mellitus (T2DM) with poor glycemic control when treated with metformin monotherapy.

Methods: A total of 274 patients with T2DM were randomized (1:1) to either arm X, receiving FDC of dapagliflozin (10 mg) + sitagliptin (100 mg) + metformin hydrochloride XR (1000 mg) (Dapa + Sita + Met) tablets, or arm Y, receiving sitagliptin phosphate (100 mg) + metformin hydrochloride XR (1000 mg) (Sita + Met) tablets, and treated for 16 weeks.