Associations of low-carb diets with glycaemic control and diabetic complications among adult Ghanaians: the RODAM study.

Purpose: We aimed to determine the associations of low-carb diets with glycated haemoglobin (HbA1c) and diabetes complications among Ghanaian adults, who traditionally rely on carbohydrate-dense diets and experience a high prevalence of type 2 diabetes (T2DM).

Methods: This analysis used baseline data of the multi-centre RODAM (Research on Obesity and Diabetes among African Migrants) Study among Ghanaian adults (N = 5,898; 18-96 years) living in Ghana and Europe. Energy (kcal/d) and macronutrient intakes (energy%) were computed from the semi-quantitative Ghana Food Propensity Questionnaire.

Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research.

The All of Us Research Program (All of Us) seeks to accelerate biomedical research and address the underrepresentation of minorities by recruiting over 1 million participants across the United States. A key question is how self-identification with discrete, predefined race and ethnicity categories compares to genetic variation at continental and subcontinental levels. To contextualize the genetic variation in All of Us, we analyzed ∼2 million common variants from 230,016 unrelated whole genomes using classical population genetics methods alongside reference panels such as the 1000 Genomes Project, Human Genome Diversity Project, and Simons Genome Diversity Project.

Cardiovascular Disease Burden among African Migrants.

Purpose Of Review: To provide an overview of the current available evidence on the burden of cardiovascular diseases (CVD) among African migrants, including its risk factors, underlying mechanisms, and prevention and treatment efforts, while highlighting critical gaps in knowledge.

Recent Findings: The CVD burden is high among most African migrant populations. Underlying mechanisms for the high CVD burden include various pre- and post-migration factors, genetics, and epigenetics.

Counting Temporal Paths.

This work investigates the parameterised complexity of counting temporal paths. The problem of counting temporal paths is mainly motivated by temporal betweenness computation. The betweenness centrality of a vertex is an important centrality measure that quantifies how many optimal paths between pairs of other vertices visit .

Gut microbiota shift in Ghanaian individuals along the migration axis: the RODAM-Pros cohort.

Migration is associated with a substantial change in environmental exposures and health outcomes. We aimed to investigate the shift in gut microbiota composition and the associations with cardiometabolic outcomes in the RODAM-Pros cohort spanning multiple research sites across continents. We determined gut microbiota composition of 1,177 Ghanaian participants in rural Ghana, urban Ghana, and Amsterdam, the Netherlands, using 16S rRNA sequencing.