Ligand-binding pockets in RNA and where to find them.

RNAs are critical regulators of gene expression, and their functions are often mediated by complex secondary and tertiary structures. Structured regions in RNA can selectively interact with small molecules-via well-defined ligand-binding pockets-to modulate the regulatory repertoire of an RNA. The broad potential to modulate biological function intentionally via RNA-ligand interactions remains unrealized, however, due to challenges in identifying compact RNA motifs with the ability to bind ligands with good physicochemical properties (often termed drug-like).

Correlative analysis of metallomic gene expression and metal ion content within the mouse hippocampus.

Brain metal homeostasis is essential for healthy neurological function, and disturbed brain metal homeostasis has deleterious consequences for neurodevelopment or cognitive outcome following injury or during disease. Specific regions of the brain (e.g.

Ligand-binding pockets in RNA, and where to find them.

RNAs are critical regulators of gene expression, and their functions are often mediated by complex secondary and tertiary structures. Structured regions in RNA can selectively interact with small molecules - via well-defined ligand binding pockets - to modulate the regulatory repertoire of an RNA. The broad potential to modulate biological function intentionally via RNA-ligand interactions remains unrealized, however, due to challenges in identifying compact RNA motifs with the ability to bind ligands with good physicochemical properties (often termed drug-like).

Location of capture sufficiently characterises lifetime growth trajectories in a highly mobile fish.

Variation in somatic growth plays a critical role in determining an individual's body size and the expression of its life history. Understanding the environmental drivers of growth variation in mobile organisms such as fishes can be challenging because an individual's growth expression integrates processes operating at different spatial and temporal scales. Traditionally, otolith (ear stone) based growth analyses have focussed on temporal environmental variation by assuming an individual spends its whole life at its capture location.