Multi-center Study of Hyperpolarized Xenon MRI in Children with Cystic Fibrosis Following Initiation of CFTR Modulator Therapy (HyPOINT).

Rationale: Elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved lung function in people with cystic fibrosis (CF), prompting the need for outcome measures that can detect mild disease. In this new era of CFTR modulator therapy, more sensitive endpoints are required to evaluate the progression of early lung disease and to determine the efficacy of new CF therapies. Prior to the availability of highly effective therapies 129Xenon magnetic resonance imaging (Xe MRI) was shown to be more sensitive to regional ventilation changes compared to spirometry.

Exercise and eating motivation in weight loss maintenance: revisiting the motivational spillover with the NoHoW study.

Objective: Physical activity and nutrition-related behaviors are crucial factors in maintaining weight loss. The interplay between the motivations to consistently engage in both behaviors is a fundamental yet understudied topic. The current study examines the reciprocal effects between exercise and eating motivation and their effect on steps and energy intake over a 12-month period.

Small and ultra small angle neutron scattering on pure and supramolecular composite GelMA hydrogels.

Development of highly sophisticated tissue-engineered models capable of eliciting specific health and disease states could revolutionise disease treatment. To accomplish this it requires the generation of highly sophisticated hydrogel/biomaterial systems, including materials with tuneable properties and multiscale architecture composed of structures with different sizes ranges. In developing such systems, it is crucial to quantify any structures and interactions in the nano- and micron-scale range, to determine how these systems may affect cell phenotype.