Stigma among primary care providers: characterizing attitudes and behaviors in the care of people with chronic hepatitis in the Philippines.

Background: Stigma is a key barrier to compassionate primary health care delivery and people-centered care (PCC), but is understudied among primary care providers (PCPs). Hepatitis B and C have a significant burden of disease in the Philippines, where there is limited awareness of and access to screening and treatment. Patient-reported stigma has been identified as a significant barrier to hepatitis care in the Philippines, but PCP stigma-related attitudes and behaviors have not been explored in this context.

Range extender mediates long-distance enhancer activity.

Although most mammalian transcriptional enhancers regulate their cognate promoters over distances of tens of kilobases, some enhancers act over distances in the megabase range. The sequence features that enable such long-distance enhancer-promoter interactions remain unclear. Here we used in vivo enhancer-replacement experiments at the mouse Shh locus to show that short- and medium-range limb enhancers cannot initiate gene expression at long-distance range.

Transarterial Radioembolization with Yttrium-90 and SIRT Versus Conventional Transarterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Background: Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are primary locoregional therapies for unresectable hepatocellular carcinoma (HCC). However, their comparative efficacy remains debated. We aimed to systematically review and meta-analyze the evidence comparing TARE (Yttrium-90 or SIRT) versus TACE (conventional or drug-eluting bead) for intermediate or advanced HCC.

Indirect reciprocal facilitation promotes species coexistence in plant communities worldwide.

Plant-plant facilitation is key to supporting species persistence within communities. However, as beneficiary species mature and compete with their benefactors, competition appears to dominate, suggesting that facilitation has a limited role in long-term community structuring. Here, we propose that facilitation can consistently enhance diversity when it occurs reciprocally between interacting species.

Universal videolaryngoscopy for tracheal intubation in the operating theatre: A prospective non-randomised clinical trial.

Introduction: Multiple trials have shown the advantages of videolaryngoscopy over direct laryngoscopy for tracheal intubation in the operating theatre. However, the effectiveness of universal videolaryngoscopy in real-world operating theatre settings remains uncertain.

Methods: We conducted a prospective, multicentre, quasi-experimental study, to evaluate the effectiveness of universal videolaryngoscopy compared with direct laryngoscopy for tracheal intubation in a real-world operating theatre setting.