Bridging the Gut Microbiota and the Brain, Kidney, and Cardiovascular Health: The Role of Probiotics.

The symbiosis between intestinal bacteria and the human body's physiological processes can modulate health. The intestinal microbiota is linked to the development of neurotrophic factors; therefore, it is increasingly related to the modulation of nervous system pathologies. Moreover, microbiota can interfere with inflammation and oxidative stress, which are closely linked to cardiovascular risk factors and several other inflammatory conditions, such as kidney and neurodegenerative diseases.

Computational Profiling of Monoterpenoid Phytochemicals: Insights for Medicinal Chemistry and Drug Design Strategies.

Monoterpenoids are a structurally diverse class of natural products with a long-standing history of therapeutic use. Despite their promising bioactivities, their clinical development has been limited by dose-dependent toxicities, poor pharmacokinetics, and suboptimal drug-like properties. In this work, a comprehensive in silico pipeline was employed to evaluate 1175 monoterpenoid compounds retrieved from ChEBI, aiming to identify structurally diverse candidates that possess favorable drug-like characteristics.

Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in maxillary sinus lift surgeries: a systematic review.

Sinus lift surgery is essential after pneumatization caused by loss of posterior teeth. Leukocyte-Platelet-Rich Fibrin (L-PRF) accelerates bone healing by releasing growth factors that promote angiogenesis, cell differentiation, and inflammatory modulation. To evaluate the efficacy of L-PRF in bone healing and repair in sinus lift surgeries, in addition to investigating its role in angiogenesis and inflammatory modulation.

Inhibition of glucagon secretion from pancreatic α-cells by the bile acid TUDCA involves a S1PR2-PI3K pathway.

The global prevalence of type 2 diabetes (T2D) continues to rise, and predictions indicate alarming records in coming decades. Although pancreatic β-cell dysfunction and insulin resistance are key factors in the etiology of T2D, the impairment of α-cells has been also implicated. Hyperglucagonemia and altered suppression of glucagon release can be frequently found in individuals with T2D, contributing to hyperglycemia.

Premature ovarian insufficiency: Updated concepts in diagnosis and hormonal treatment strategies.

Objective: To provide an updated overview of Premature Ovarian Insufficiency (POI), focusing on the current evidence regarding diagnosis, hormonal treatment, and clinical management.

Methods: A narrative review was conducted using data from the FEBRASGO protocol and updated international guidelines, complemented by recent publications from PubMed and Scopus.

Results: POI affects up to 3.