A chlorinated diketopiperazine antibiotic targets .

We describe a novel macrocyclic peptide, speirobactin, produced by that selectively kills . A nonribosomal peptide synthase containing two linear modules codes for the synthesis of speirobactin. The biosynthetic operon contains a pentapeptide-repeat protein as a resistance gene.

Intensified conditioning with high-dose total marrow irradiation and myeloablative chemotherapy reduces risk of relapse without increasing toxicity in allogeneic hematopoietic stem cell transplant for high-risk myeloid malignancies: a phase II study.

The intensity of the conditioning regimen in hematopoietic stem cell transplantation (HSCT) correlates with the risk of relapse, however its potential benefit may be outweighed by the associated risk of toxicity. The addition of total marrow irradiation (TMI) to myeloablative conditioning provides an opportunity to increase intensity with minimal additional toxicity. In this phase 2 clinical trial, 30 patients with high-risk myeloid malignancies received an allogeneic HSCT using myeloablative TMI at 9Gy in combination with standard myeloablative fludarabine/intravenous busulfan (FluBu4) chemotherapy.

An Explainable-AI Based Approach Towards Measuring Cognitive Reserve.

Cognitive Reserve (CR) refers to the brain's ability to compensate for brain damage or age-related changes, which can explain why some individuals show greater cognitive resilience to brain pathology despite damage or age-related changes. Understanding CR is crucial for identifying factors that contribute to cognitive decline among individuals. Currently, there is no direct, valid and widely accepted method for quantifying CR.

Persistent opioid use is associated with a shorter myeloma survival.

Purpose: Overuse of opioids has been associated with a significant public health crisis, yet remain critical as adjunctive treatment in multiple myeloma (MM). Questions remain about the balance between the benefits to risks of ongoing opioid use, especially when the patient's myeloma is in remission. This retrospective review focuses on the association of chronic opioid use (COU) in a patient population predominantly people of color.

A Chlorinated Diketopiperazine Antibiotic Targets DNA Gyrase.

We describe a novel macrocyclic peptide, speirobactin, produced by that selectively kills . A non-ribosomal peptide synthase (NRPS) containing two linear modules codes for the synthesis of speirobactin. The biosynthetic operon contains a pentapeptide-repeat protein as a resistance gene.