The evolution of cancer and ageing: a history of constraint.

Ageing and cancer are ubiquitous in animals. They are fundamental and generally intrinsic to multicellular life. Nonetheless, ageing and cancer rates vary widely across species and understanding their evolution and interaction is of great biological interest.

Vaccinia virus modulates the redox environment by inhibiting reactive oxygen and nitrogen species with increased activity of endogenous antioxidant enzymes.

The vaccinia virus (VACV) is the most studied and well-characterised member of the Poxviridae family. However, the mechanisms through which it modulates redox homeostasis in host cells remain unclear. Although oxidative stress, which is marked by elevated levels of reactive species, contributes to the pathogenesis of many viral infections, poxviruses may adopt distinct strategies.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs.

The dynamics of lifespan are shaped by DNA variants that exert effects at different ages. We have mapped genetic loci that modulate age-specific mortality using an actuarial approach. We started with an initial population of 6,438 pubescent siblings and ended with a survivorship of 559 mice that lived to at least 1100 days.

Four days of a moderate dose of caffeine does not alter raw bioelectrical impedance analysis parameters in healthy males.

Background And Aims: This study investigated the effects of a moderate caffeine dose on resistance (R), reactance (Xc), impedance (Z), capacitance (Cap), and phase angle (PhA) over four days in males. Thirty men aged 20-39 years, with low caffeine consumption (<100 mg/day), participated in this double-blind, randomized crossover trial (ClinicalTrials.gov: NCT01477294).

Bacterial profile and antimicrobial resistance in diabetic foot ulcer infections: a 10-year retrospective cohort study.

Introduction: Diabetic Foot Infections (DFI) are severe complications of diabetes, often resulting in poor clinical outcomes, including amputations. The objective of this study is to identify the main pathogens causing infections in the diabetic foot ulcers, as well as the antibiotic resistance profile.

Methods: This study included all patients treated for diabetic foot infections at a private tertiary hospital between 2013 and 2022.