Personalizing elective oocyte cryopreservation: a novel predictive model for oocyte yield across multiple stimulation cycles.

Study Question: Can patient age and ovarian reserve tests predict the number of cryopreserved oocytes in patients undergoing one or more ovarian stimulation cycles for elective oocyte cryopreservation (EOC)?

Summary Answer: A predictive model incorporating patient age, antral follicle count (AFC), anti-Müllerian hormone (AMH), and FSH levels achieved the greatest predictive accuracy.

What Is Known Already: As a consequence of societal evolution, women are increasingly delaying starting a family. However, the natural decline in ovarian reserve and oocyte quality as age advances can increase the risk of age-related fertility decline (ARFD) and involuntary childlessness.

Molecular components of the FPR2/ALX pathway participate in astrocyte-neuron resolution responses to afford maneb-induced toxicity.

Environmental toxicants such as maneb (MB), a dithiocarbamate pesticide, trigger progressive neuronal death, probably due to the imbalance in inflammation/resolution mechanisms, resulting in the onset of neurodegeneration. The inflammation/resolution balance is governed by G protein-coupled receptor (GPCR) signaling, but it has been poorly described in the Central Nervous System (CNS), since resolution GPCR ligands are negligible and elusive lipid compounds. These mediators are mainly synthesized by lipoxygenases (ALOX) from arachidonic acid (AA) and docosahexaenoic acid (DHA) released by specific phospholipases A2 (PLA2).

Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes.

Background: Before Zika virus (ZIKV) infections were observed in the Americas, an association between ZIKV and microcephaly or other congenital malformations was not well documented. Initial reports suggested strong associations between ZIKV and congenital malformations, but plausible estimates of causal effects from prospective studies with adequate sample size and covariate data were few.

Methods: From 2016-2018, the Zika in Infants and Pregnancy (ZIP) study enrolled pregnant people before 18 weeks gestation or with confirmed symptomatic ZIKV in a prospective cohort across 10 sites in South and Central America, and in Puerto Rico.

Oxymetazoline and Blepharoptosis: A Case Series and Proposed Treatment Algorithm.

Blepharoptosis, characterized by drooping upper eyelids, affects vision and daily life. Traditional management includes observation, pharmacological treatments, and surgery, though not all cases necessitate surgical intervention. Pharmacologic treatments such as apraclonidine and phenylephrine eyedrops have been used but are limited by significant adverse effects, including pupil dilation and ocular/systemic side effects.

Does vasopressor administration in the ICU affect outcomes following primary total joint arthroplasty?

Introduction: The subset of patients admitted to the intensive care unit (ICU) following total joint arthroplasty (TJA) has yet to be studied in detail. Specifically, there is little data on the effects of vasopressor administration in patients who require critical care after TJA. We sought to characterize patient outcomes and mortality by vasopressor administration in the ICU following primary TJA.