Influence of local denture-related factors on the inflammatory marker levels in patients with denture stomatitis.

Objectives: Many denture-related factors have been identified as risk factors for DS, including trauma, nighttime denture wearing, insufficient oral and denture hygiene. The aim of this research was to examine the effects of local denture factors in the oral mucosa and saliva content that occurred after the DS onset.

Materials And Methods: The study sample comprised 150 adult partial or total denture wearers, 100 of whom were diagnosed with DS, and the remaining 50 had a healthy mucous membrane despite having prosthetic restorations and served as controls.

Natural Killer Cells in Alzheimer's Disease: From Foe to Friend.

The neuroinflammatory aspect of Alzheimer's disease (AD) has been largely focused on microglia, the innate immune cells of the brain; however, recent evidence increasingly points to the importance of multiple alterations in the systemic immune response during disease development. Natural killer (NK) cells are also components of innate immunity, whose role in AD pathogenesis has been sporadically investigated and often conflicting results have been reported. Recent clinical trial has suggested the potential beneficial effects of AD immunotherapy based on ex vivo-expanded, genetically unmodified, NK cells.

Determination of Gingival Index and Salivary Proinflammatory Cytokines (Interleukin 6 and Tumour Necrosis Factor α) After Chemical-Mechanical Retraction Procedure.

The aim of this study was to test the impact of the gingival chemical-mechanical retraction procedure on the value of the gingival index (GI) and salivary concentrations of interleukin 6 (IL-6) and tumour necrosis factor α (TNF-α). The importance of this clinical study is that it provides an exact conclusion regarding the behaviour of the gingival tissue after the application of an impregnated retraction cord in the gingival sulcus of the subjects. The research was conducted as a prospective clinical study.

Dissecting the immune response of CD4 T cells in Alzheimer's disease.

The formation of amyloid-β (Aβ) plaques is a neuropathological hallmark of Alzheimer's disease (AD), however, these pathological aggregates can also be found in the brains of cognitively unimpaired elderly population. In that context, individual variations in the Aβ-specific immune response could be key factors that determine the level of Aβ-induced neuroinflammation and thus the propensity to develop AD. CD4 T cells are the cornerstone of the immune response that coordinate the effector functions of both adaptive and innate immunity.

Lagrangian Split-Step Method for Viscoelastic Flows.

This research addresses and resolves current challenges in meshless Lagrangian methods for simulating viscoelastic materials. A split-step scheme, or pressure Poisson reformulation of the Navier-Stokes equations, is introduced for incompressible viscoelastic flows in a Lagrangian context. The Lagrangian differencing dynamics (LDD) method, which is a thoroughly validated Lagrangian method for Newtonian and non-Newtonian incompressible flows, is extended to solve the introduced split-step scheme to simulate viscoelastic flows based on the Oldroyd-B constitutive model.