nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1.

A large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have a variety of actions including antibiotic and anticancer activities and the inhibition of neuronal nitric oxide synthase. We have investigated the structure-activity relationship of citropin 1.

A phase I study of the GM-CSF antagonist E21R.

Purpose: E21R is a competitive inhibitor of GM-CSF. This is the initial clinical study to investigate the safety, toxicity and pharmacokinetics of escalating doses of E21R.

Patients And Methods: Cohorts of three patients received doses of 10, 30, 100, 300, 600 and 1000 micro g/kg per day given subcutaneously daily for 10 days.

More than a sore mouth: patients' experience of oral mucositis.

Purpose/objectives: To explore patients' experience of chemotherapy-induced oral mucositis.

Design: Interpretive descriptive, phenomenologic.

Setting: The cancer center of a metropolitan teaching hospital in South Australia.

Cancer patients' perceptions of do not resuscitate orders.

Patients' perceptions of do not resuscitate (DNR) orders and how and when to present the information were sought to aid in framing DNR policy. Semi-structured interviews of 23 patients being treated for cancer, were conducted by a clinical psychologist. The interviews were transcribed and analysed with the aid of a qualitative software package.

The discursive properties of "hope": a qualitative analysis of cancer patients' speech.

The authors of this article question the usefulness of the empirico-realist search for a definitive definition of hope. Semistructured interviews on "do-not-resuscitate" issues with 23 oncology clinic outpatients were tape-recorded, transcribed, and analyzed following grounded-theory methodology and discursive analytical methodology. Twelve patients spontaneously spoke about hope as objective or subjective, a burden or a resource.