Optogenetic tools and their applications for therapeutic intervention in end-stage inherited retinal diseases.

Retinal degenerative diseases pose significant therapeutic challenges; however, optogenetic vision restoration offers a promising strategy that is independent of mutations and disease progression. Optogenetic tools consisting of photosensitive membrane proteins can be ectopically expressed in retinal cells, effectively converting them into artificial photoreceptors. This review outlines the development and application of optogenetic tools to restore light sensitivity in degenerated retinas.

Bicaval TricValve Implantation in Patients With Severe Tricuspid Regurgitation: 1-Year Outcomes From the TricBicaval Registry.

Background: Caval valve implantation is currently the only alternative for patients with severe tricuspid regurgitation (TR) who are deemed unsuitable candidates for transcatheter orthotopic therapies.

Objectives: The aim of this study was to assess the efficacy and safety of TricValve system at 1-year follow-up.

Methods: TricBicaval registry is a multicenter registry that retrospectively enrolled all consecutive patients with severe TR treated with TricValve system.

The Metacontinuum: Bridging cellular composition to cognitive functions in brain organization.

Brain organization emerges from molecular, cellular, and systems-level processes that together generate cognitive function. While individual biological codes have been characterized at specific scales, their integration across levels remains poorly understood. Existing theories of consciousness recognize diverse electrophysiological signatures but fail to explain the continuity linking molecular and neural codes.

The Lipid Interactome: An interactive and open access platform for exploring cellular lipid-protein interactomes.

Lipid-protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has long been hindered by the inherent biochemical properties of lipids. Recent advances in functionalized lipid probes - equipped with photoactivatable crosslinkers, affinity handles, and photocleavable protecting groups - have enabled proteomics-based identification of lipid interacting proteins with unprecedented specificity and resolution. Despite the growing number of published lipid interactomes, there remains no centralized effort to harmonize, compare, or integrate these datasets.

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility.

The innate immune gene 33, encoding a myeloid inhibitory sialic acid-binding receptor, is associated with Alzheimer's disease (AD) susceptibility. The AD-associated risk variant reduces splicing of the sialic acid-binding domain and increases expression of the full-length (sialic acid-binding) CD33 isoform seven-fold compared to the protective genotype. Here we identify CD45 as an immune cell-specific sialic acid-dependent CD33 binding partner, whose phosphatase activity is inhibited by CD33.