Mandibular Advancement Device versus CPAP in Severe Obstructive Sleep Apnea.

Severe obstructive sleep apnea (OSA) is linked to adverse cardiovascular outcomes. While continuous positive airway pressure (CPAP) is the standard treatment, mandibular advancement devices (MADs) offer an alternative. This substudy of a randomized trial compared the effectiveness of MADs versus CPAP on 24-h ambulatory blood pressure (BP), sleep-related quality of life, myocardial remodeling, ambulatory heart rhythm, and biomarkers in severe OSA.

Uncovering the heterogeneity in young adult anxiety: subtypes predict outcomes of a CBT mobile app.

App-based interventions are scalable and effective in reducing anxiety in young adults. Still, two-thirds of young adults remain symptomatic. Uncovering the heterogeneity in young adult anxiety by identifying clinical subtypes can guide precision interventions that match individuals' profiles.

A porcine model of acute rejection for cardiac transplantation.

machine perfusion has been growing in utility for preserving donor organs prior to transplantation. This modality has tremendous potential for bioengineering and conditioning organs prior to transplantation using small molecule or advanced therapeutics. To safely translate potential interventions, well characterized models of disease are crucial for testing the therapeutic and possible side effects that could manifest from the interventions.

The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort.

Background: Elevated Glial Fibrillary Acidic Protein (GFAP) is associated with increased Phosphorylated Tau 181 (pTau181) induced neurodegeneration in Alzheimer's Disease.

Objective: However, the role of GFAP and pTau181 in vascular/mixed dementias requires elucidation within the Southeast Asian context, where their burden is considerable.

Design: Population based cross-sectional study.