Publications by authors named "F Atassi"
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra, which is accompanied by immune dysfunction and chronic inflammation. Peripheral monocytes, key players in systemic inflammation, cross the blood-brain barrier and alter PD etiology and progression. To define the role of peripheral monocytes, cross-sectional studies of RNA transcripts isolated from PD monocytes were compared with age- and sex-matched control monocytes.
View Article and Find Full Text PDFUveal melanoma (UM) is the most common primary intraocular malignancy in the adult eye. Despite the aggressive local management of primary UM, the development of metastases is common with no effective treatment options for metastatic disease. Genetic analysis of UM samples reveals the presence of mutually exclusive activating mutations in the Gq alpha subunits GNAQ and GNA11.
View Article and Find Full Text PDFT-cell dysregulation and inflammatory process in ()-deficient rats in basal and stress conditions.
Am J Physiol Lung Cell Mol Physiol
May 2023
Article Synopsis
- Hereditary pulmonary veno-occlusive disease (hPVOD) is caused by mutations in the GCN2 gene, which is linked to severe pulmonary hypertension.
- Research involved creating mutant rat lines to study lung responses to amino acid deprivation, specifically after administering PEG-asparaginase (ASNase).
- Findings showed increased inflammation in the lungs, changes in immune cell populations, and a lack of integrated stress response activation, suggesting insights into hPVOD mechanisms and immune system roles.
Background Platelet-derived growth factor is a major regulator of the vascular remodeling associated with pulmonary arterial hypertension. We previously showed that protein widely 1 (PW1) vascular progenitor cells participate in early vessel neomuscularization during experimental pulmonary hypertension (PH) and we addressed the role of the platelet-derived growth factor receptor type α (PDGFRα) pathway in progenitor cell-dependent vascular remodeling and in PH development. Methods and Results Remodeled pulmonary arteries from patients with idiopathic pulmonary arterial hypertension showed an increased number of perivascular and vascular PW1 cells expressing PDGFRα.
View Article and Find Full Text PDFBackground: To evaluate the association between donors' and recipients' serum levels of soluble ST2 (sST2) and recipients' outcome after heart transplantation (HT).
Methods: Blood samples were collected in 50 heart donors before organ procurement and in 50 recipients before HT (D0), a week after HT (D7) and at every first year's endomyocardial biopsy (EMB); sST2 levels were evaluated by ELISA.
Results: Donors who sustained a cardiac arrest, had significantly higher sST2 levels.