Phosphatidylserine translocation, cholesterol spatial distribution, and acrosome reaction reliably distinguish sperm capacitation from cryoinjury in bovine sperm.

Sperm capacitation is a critical process for successful fertilization, involving multiple regulated cellular changes. On the other hand, cryopreservation induces membrane changes that can mimic capacitation, potentially leading to misinterpretation of sperm function. Distinguishing true capacitation from cryoinjury remains challenging, as both share surface markers despite involving distinct mechanisms and impacts on fertilization.

Incidence and persistence of internalizing disorders from late childhood to young adulthood: an 8-year follow-up analysis of a community-based cohort.

Background: Internalizing disorders are common and impairing in youth, often continuing into adulthood. While clinical samples emphasize their persistence, non-clinical cohorts using dimensional approaches reveal diverse trajectories. However, few population-based studies have examined internalizing disorders as categorical outcomes while identifying clinically relevant predictors.

Clinical properties of the short mood and feelings questionnaire: Development of a free calculator based on the Brazilian high-risk cohort study.

Background: The Short Mood and Feelings Questionnaire (SMFQ) is a validated tool for assessing depressive symptoms in youth, though no specific cut-point exists for the Brazilian population. Item response theory (IRT) and interval likelihood ratios (ILRs) offer refined methods to monitor symptoms but involve complex calculations that hinder clinical implementation.

Methods: Cross-sectional data were drawn from an urban school-based sample (Brazilian High-Risk Cohort Study in 2018-2019, n = 1,905, aged 14-23, 46.

Parent Psychological Well-Being, Home Learning Environment, and Child Development among Kenyan Families.

While child poverty is declining globally, many children in Sub-Saharan Africa still live in poverty and face obstacles that hinder them from achieving their full developmental potential. Parents' psychological well-being has important influences on child development directly or indirectly through the home learning environment (HLE). Still, there is a lack of research on this topic from Sub-Saharan Africa.

Protocol for a hybrid type I randomized controlled trial evaluating the effectiveness and implementation of a nurse home visiting program for adolescent pregnancy on maternal and infant outcomes.

Background: Adolescent pregnancy poses significant public health challenges, particularly among vulnerable populations. Nurse home visiting programs, such as , show promise in improving maternal and child health outcomes, yet their integration into primary healthcare remains underexplored, especially in low-resource settings.

Aim: to evaluate the effectiveness and feasibility of integrating into primary healthcare services across two municipalities of the state of São Paulo, Brazil.