Lessons learned from a formalized peer mentoring program in a baccalaureate nursing curriculum.

Background: Formal mentoring within the nursing profession has been recognized as an effective approach in teaching critical thinking, leadership skills, communication, and professional socialization. Unfortunately, few baccalaureate nursing programs teach skills specific to mentoring, both as mentees and mentors within a formalized program.

Methods: A peer mentoring program with senior students mentoring sophomore students was developed based on Benner's (1984) novice-to-expert theory during the COVID-19 pandemic.

Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.

Background: The benefits of oral corticosteroid (OCS) stewardship approaches -including monoclonal antibody treatments for severe asthma- on reducing toxic OCS exposure and related comorbidities such as depression and anxiety require real-world evaluation.

Methods: This real-world observational study investigated OCS exposure and associated complications over 24 months in patients enrolled in the Australian Mepolizumab Registry (n = 412).

Results: Patients were median age 59 years, 58 % were female.

Overcoming the barriers to treatment of rare cancer patients in the era of precision oncology: A call to action.

Rare cancers account for a quarter of cancer diagnoses in Europe yet clinical research, diagnosis, treatment access, and survival outcomes lag significantly behind common cancers. Despite the potential of precision oncology, the consistent implementation of comprehensive genomic profiling in routine clinical practice and robust evidence-generation remains a challenge in this population, compounded by regulatory hurdles and a lack of investment in drug development. A concerted effort across all stakeholders is required to optimise diagnostics, including access to molecular profiling, to expedite clinical trials and treatment access, and to gather high-quality data, including patient-reported outcomes, in rare cancers.

B(CF)-Catalyzed Coupling of -Alkyl Arylamines and Alkenes for the Synthesis of Tetrahydroquinolines.

Tetrahydroquinolines are featured in molecules with wide ranging properties, including those with biological activity and materials applications. This report demonstrates that widely accessible -alkyl arylamines can be directly coupled with new classes of alkenes to synthesize tetrahydroquinolines. The reaction is facilitated by a commercially available borane catalyst and enables the creation of novel tetrahydroquinoline scaffolds.

A programmable modular robot for the synthesis of molecular machines.

The assembly of molecular nanomachines using atomically precise manipulations promises to enable nanotechnology with unprecedented architectural features and exquisite functional properties. However, this future is critically limited by the ability to autonomously manufacture nanomachines, with current efforts being heavily labor intensive. A system is needed to program and assemble matter under digital control, unifying molecular nanotechnology and macroscale chemical processes.