Latent space-based modeling for spectral prediction in generative photonics design.

Electromagnetic (EM) metasurfaces consist of periodic structures of sub-wavelength dimensions that exhibit the ability to manipulate light for many novel applications. Calculating the optical response of a metasurface, typically performed using in simulation, is a time- and resource-intensive operation. To accelerate computational design, machine learning-based surrogate models are increasingly investigated.

Anti-Inflammatory Activity of Ensifentrine: A Novel, Selective Dual Inhibitor of Phosphodiesterase 3 and Phosphodiesterase 4.

Ensifentrine is a novel, low-molecular-weight molecule that is a selective, dual inhibitor of phosphodiesterase (PDE)3 and PDE4. Inhibition of PDE3 has been shown to relax airway smooth muscle and inhibition of PDE4 to inhibit inflammatory responses and to stimulate the cystic fibrosis transmembrane conductance regulator in human airway epithelial cells through accumulation of intracellular cyclic adenosine monophosphate. Additionally, the dual inhibition of PDE3 and PDE4 demonstrates enhanced or synergistic effects compared with inhibition of either PDE3 or PDE4 alone on contraction of airway smooth muscle and suppression of inflammatory responses.

Can Graduate Students Rate Personality Reliably in Psychoanalytic Treatments Using the Shedler-Westen Assessment Procedure (SWAP-200)?

Psychotherapy researchers often recruit students to code psychotherapy process and outcome variables on individual therapy sessions. To do so, graduate students read verbatim psychotherapy transcripts, listen to audio or watch video of psychotherapy sessions, and then rate process and outcome measures on these sessions. Although prior studies have investigated the reliability and validity of graduate student ratings of personality dysfunction, no current study has investigated the reliability and validity of these ratings made on the basis of psychotherapy transcripts and audio.

New Eye Drop Formulation Based on Desonide and Xanthan Gum in Dry Eye Disease: Nonclinical Studies.

A novel ophthalmic formulation, XanterDES, containing 0.2% xanthan gum and 0.025% desonide sodium phosphate (DES), was developed to alleviate ocular surface discomfort and irritation.

An updated meta-analysis of the relation between adult attachment style and working alliance.

Previous meta-analyses have shown that client-rated working alliance is negatively correlated with attachment anxiety and attachment avoidance. The purpose of this study is to provide an updated meta-analysis of the relation between alliance and the two dimensions of attachment insecurity. Random effects models were used to examine the relation between the working alliance and attachment anxiety and the relation between the working alliance and attachment avoidance.