Probiotic Bacteria as Therapeutics and Biohybrid Drug Carriers: Advances, Design Strategies, and Future Outlook.

Probiotic bacteria have emerged as versatile and biocompatible platforms for drug delivery, offering a safe and efficient means of targeting diseased tissues. Advances in nanotechnology and genetic engineering have significantly expanded the potential of probiotic bacteria in precision medicine, enabling the delivery of therapeutics, proteins, antigens, and nanoparticles (NPs). This review explores diverse strategies for utilizing probiotics as drug carriers, including bacterial ghosts, outer membrane vesicles (OMVs), surface membrane proteins, and spores, focusing on applications in cancer therapy, vaccine development, and gastrointestinal disorders.

Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals.

The progression of inflammation during sepsis represents a multifaceted biological cascade that requires effective therapeutic interventions to improve survival. In septic neonatal foals, oxidative stress (OS) arises due to a compromised antioxidant defense system. Oxidative stress may disrupt the functionality of redox-sensitive organelles, such as the endoplasmic reticulum (ER).

Computational identification of dual COX-1 and NIK inhibitors from marine microalga Chlorella vulgaris.

The search for safe and effective anti-inflammatory agents remains a critical area of research due to the widespread impact of chronic inflammatory diseases. Natural compounds, particularly those derived from marine sources, present a promising avenue for developing novel therapeutics. In this study, we investigated the potential of Chlorella vulgaris, a unicellular green alga with a rich profile of bioactive compounds, as a source of anti-inflammatory agents.

Antimicrobial Effect of Ultraviolet C (UV-C) Light Compared to Standard Povidone-Iodine Protocol for Preoperative Disinfection of the Periocular Area.

Objective: To evaluate the antimicrobial effect of 275 nm wavelength ultraviolet C (UV-C) light on the periocular area of canine eyes for preoperative disinfection compared to standard 10% povidone-iodine (PI) solution preparation.

Methods: The upper and lower eyelids of six research-bred beagles were equally divided into two sections (medial and lateral). Each section received periocular cleansing with one of the following treatments: (1) saline, (2) baby shampoo, (3) baby shampoo and PI solution, or (4) baby shampoo and UV-C light therapy.

Implementing type and screen method replacing conventional antiglobulin crossmatch procedure for compatibility testing in elective protocol in a tertiary care hospital.

Introduction: Pretransfusion testing is an essential and important investigation to provide safe and fully compatible packed red blood cell (PRBC) unit to the recipient to prevent the fatal hemolytic transfusion reaction. Type and screen (T and S) procedure is one of the effective approaches in pretransfusion testing in which antibody screen (AS) negative recipients are transfused with an immediate saline phase compatible PRBC unit. In order to explore the feasibility of implementing T and S protocol in our institute, this study was carried out.